Yeast copper-zinc superoxide dismutase activity

Gralla EB, Thiele DJ, Silar P, Valentine JS. ACE1, a copper-dependent transcription factor, activates expression of the yeast copper, zinc superoxide dismutase gene. Proc Natl Acad Sci USA 88 8558-8562, 1991. 

Superoxide dismutases have been isolated from a wide variety of eukaryotes including yeast, wheat germ, garden peas, chicken liver and erythrocytes. These enzymes contain copper and zinc. Copper containing proteins which also display this catalytic activity had been isolated from blood, brain and liver tissues many years previously and were known as erythrocuprein, cerebrocuprein and hepatocuprein. 

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