Y- -L-glutamic acid

Figure 16 Scheme of the lamellar structure of the poly(y, L-glutamic acid)-dodecyltrimethylamonium complexes viewed parallel to the layers and perpendicular to the a-helices axes. (Taken from E.A. Ponomarenko, A.J. Waddon, K.N. Bakeev, D.A. Tirrell, and W.J. MacKnight. Macromolecules 29 4340, 1996. With permission.)... 

Stoichiometric complexes of poly(L-lysine) cations and dodecyl sulfate anions were investigated by Ponomarenko et al. [51,52]. The complexes are prepared by the same method used in the preparation of poly(y,L-glutamic acid)-alkyltrimethylammonium complexes. The secondary stmcture adopted by the polypeptide in these complexes was found to be very susceptible to environmental conditions. In chloroform solution containing 1 to 2% (v/v) TFA the polypeptide chain is in the a-helical con formation whereas a disordered state is present at TFA concentrations above 5%. It was interesting to observe that a noticeable decrease in the spin-lattice relaxation time accompanied the helix-coil... 

Stoichiometric complexes of poly(L-lysine) cations and dodecyl sulfate anions were investigated by Ponomarenko et al. [48,49]. The complexes are prepared by the same method used in the preparation of poly(Y,L-glutamic acid)-alkyltri-... 

Kadokawa, J., Setoguchi, T, and Yamamoto, K. [2013). Preparation of highly flexible chitin nanofiber-graft-poly[y-L-glutamic acid) network film, Polym. Bull, 70,3279-3289. 

Preparation of poly-a-L-glutamic acid-y-(f-butyl)ester... 

Hirabayashi, H., Nishikawa, M., Takakura, Y., and Hashida, M. Development of pharmacokinetics of galactosylated poly-L-glutamic acid as a biodegradable carrier for liver-specific drug delivery. Pharm. Res. 13 880-884, 1996. 

Scheme 13 Chemical structure of poly(L-glutamic acid) containing triphenylmethane dyes in the side chains (XXII, Y =-OH and...

Azotomycin is anticancer antibiotic produced by Streptomyces ambofaciens. Total sythesis of it from y-benzyl-N-tert-butyloxycarbonyl-L-glutamic acid (y-OBzi-N-Boc-L-Glu) has been accomplished in nine steps. The mixed carbonic anhydride method was chosen for peptide bond formation. Commerically available y-OBzi-N-Boc-L-Glu was esterified with ethereal diazomethane, deprotected with trifluoroacetic acid-methylene chloride (1 1), and converted to hydrochloride y-benzyl-L-glutamic acid a-methyl ester (y-OBzi-L-Glu-a-OMe HCI) by treatment with dry hydrogen chloride in ethyl ether, MP 129°-135°C (dec.) [a]D25= + 13.3° (CHCI3). 

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