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Y-fibrinogen

Figure 7.29. Single residue (A) and mean residue (B) hydrophobicity plots of human y-fibrinogen. The most striking feature of the mean residue plot is the hydrophobic sequence, residues 337 to 379, experimentally shown to provide the Ea site for interaction with the a-chain amino-terminus on removal of the A peptide and exposure of GPRP and its surrounding hydrophobic residues for association with the hydrophobic domain of the Ea site shown in Figure... Figure 7.29. Single residue (A) and mean residue (B) hydrophobicity plots of human y-fibrinogen. The most striking feature of the mean residue plot is the hydrophobic sequence, residues 337 to 379, experimentally shown to provide the Ea site for interaction with the a-chain amino-terminus on removal of the A peptide and exposure of GPRP and its surrounding hydrophobic residues for association with the hydrophobic domain of the Ea site shown in Figure...
Accordingly, by simple inspection of the mean hydrophobicity plot for y-fibrinogen, we see the activation of fibrinogen as the emergence of a site for hydrophobic association with the most hydrophobic sequence in a second molecule. [Pg.292]

A method for the fractionation of plasma, allowing albumin, y-globulin, and fibrinogen to become available for clinical use, was developed during World War II (see also Fractionation, blood-plasma fractionation). A stainless steel blood cell separation bowl, developed in the early 1950s, was the earhest blood cell separator. A disposable polycarbonate version of the separation device, now known as the Haemonetics Latham bowl for its inventor, was first used to collect platelets from a blood donor in 1971. Another cell separation rotor was developed to faciUtate white cell collections. This donut-shaped rotor has evolved to the advanced separation chamber of the COBE Spectra apheresis machine. [Pg.519]

Fibrinogen (factor I, 340 kDa see Figures 51-1 and 51-4 and Tables 51-1 and 51-2) is a soluble plasma glycoprotein that consists of three nonidentical pairs of polypeptide chains (Aa,Bpy)2 covalently linked by disulfide bonds. The B(3 and y chains contain asparagine-linked complex oligosaccharides. All three... [Pg.601]

Figure 51-4. Diagrammatic representation (not to scaie) of fibrinogen showing pairs of Aa, B 3, and y chains iinked by disuifide bonds. (FPA, fibrinopeptide A FPB, fibrinopeptide B.)... Figure 51-4. Diagrammatic representation (not to scaie) of fibrinogen showing pairs of Aa, B 3, and y chains iinked by disuifide bonds. (FPA, fibrinopeptide A FPB, fibrinopeptide B.)...
Fig. 3. Fibrinogen molecule with its two A a, two B 3, and two -y chains. Thrombin (Ha) acts on the A a chain to generate fibrinopeptide A (FPA) and the a-chain. It also cleaves the B 3 chain to generate fibrinopeptide B (FPB) and the p-chain. S-S represents disulfide bonds. Altogether, 29 disulfide bonds hold together the six polypeptide chains that make up the fibrinogen molecule. Fig. 3. Fibrinogen molecule with its two A a, two B 3, and two -y chains. Thrombin (Ha) acts on the A a chain to generate fibrinopeptide A (FPA) and the a-chain. It also cleaves the B 3 chain to generate fibrinopeptide B (FPB) and the p-chain. S-S represents disulfide bonds. Altogether, 29 disulfide bonds hold together the six polypeptide chains that make up the fibrinogen molecule.
Lucas M. A., Fretto L. S., McKee P. A. The relationship of fibrinogen structure to plasminogen activation and plasmin activity during fibrinolysis. Ann N Y Acad Sci 1983 408, 71-91. [Pg.165]

Kamura T Tsuda H., Yae Y., et al. An abnormal fibrinogen Fukuoka II (Gly-B(315- CY5) characterized by defective fibrin lateral association and mixed disulfide formation. J Biol Chem 1995 270,29392-9. [Pg.167]

Fibrinogen (factor I) is a large (340 kDa) glycoprotein consisting of two identical tri-polypeptide units, a, P and y. Its overall structural composition may thus be represented as (a P y)2. [Pg.334]

Tyrosine (Tyr or Y) (4-hydroxyphenylalanine ((5)-2-amino-3-(4-hydroxyphenyl)-propanoic acid)) is a polar, neutral, aromatic amino acid with the formula H00CCH(NH2)CH2C6H50H and is the precursor of thyroxin, dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline), and the pigment melanin. Being the precursor amino acid for the thyroid gland hormone thyroxin, a defect in this may result in hypothyroidism. Tyr is extremely soluble in water, a property that has proven useful in isolating this amino acid from protein hydrolysates. The occurrence of tyrosine- 0-sulfate as a constituent of human urine and fibrinogen has been reported. ... [Pg.674]

Bovine senun albumin y-Globulin Fibrinogen Rabbit anti-mouse Thymocyte IgG Concavalin A Human serum albumin BK 19.45 IgG BK 19.9 IgG Rabbit IgG (polyclonal) (carrier free)... [Pg.71]

Sazuka, M., Itoi, T., Suzuki, Y., Odani, S., Koide, T., and Isemura, M., Evidence for the interaction between (—)-epigallocatechin gallate and human plasma proteins fibronectin, fibrinogen, and histidine-rich glycoprotein, Biosci. Biotechnol. Biochem., 60, 1317, 1996. [Pg.362]

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See also in sourсe #XX -- [ Pg.288 ]



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Fibrinogen

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