Xxvii metabolism

H. Markowitz, G.E. Cartwright, and M.M. Wintrobe, Copper metabolism. XXVII. Isolation and properties of an erythrocyte cuproprotein (erythrocuprein). J. Biol. Chem. 234, 40-45 (1959). 

Metabolism. XXVII. Isolation and Properties of Erythrocyte Cupro-protein (Erythrocuprein), /. Biol Chem, (1959) 234, 40-45. 

When metabolized, phenylbutazone yields two hydroxylated derivatives . The first is oxyphenbutazonc, the properties of which are described above the second contains an alcoholic hydroxyl group in the butyl side-chain XXVIII, R = (GH2)2-CHOHMe, R = Ph). This compound is devoid of anti-inflammatory activity but has enhanced uricosuric potency. Other derivatives with a modified side-chain show increased uricosuric activity associated with anti-inflammatory action. The most important are the phenylthioethyl analogue (G25671, XXVIII, R = (CH2)2-SPh, R = Ph) and its metabolite sulphinpyrazone (Anturan, XXVII, R = (CH2)2-SOPh, R = Ph). 

Another polyol dehydrogenase has been found in seminal gland. This requires TPN and converts sorbitol to glucose (XXVII). The formation of an aldose contrasts with the formation of ketose by the other polyol dehydrogenases. The combined action of the TPN and DPN enzymes concerned with sorbitol metabolism may account for the accumulation of fructose by seminal vesicles. 

Baba S, Furuta T, Fujioka M, Gorotnani T. Studies on drug metabolism by use of isotopes XXVII urinary metabolites of rutin in rats and the role of intestinal microflora in the metaboUsm of rutin. J Pharm Sci 1983 72 1155-1158. 

---