Xestospongia genus

Isomarinone (1679), an isomer of the previously known marinone (7), was isolated from the same tropical sediment bacterium (1638). Another marine-derived bacterium related to the genus Streptomyces has yielded the novel azamerone (1680) (1639). The British Columbian medicinal plant Moneses uniflora contains the antibiotic 8-chlorochimaphilin (1681), which is more active than chimaphilin (1640). Sesame roots (Sesamum indicum) have yielded the red chlorinated naphthoquinone chlorosesamone (1682) (1641). Cultures of Streptomyces strain LL-A9227 produce chloroquinocin (1683), which has some antibacterial activity against Gram-positive bacteria (1642). The two xestoquinones 1684 and 1685 were characterized from the Philippino sponge Xestospongia sp., and display topoisomerase II activity (1643). 

New manzamine alkaloids from a sponge of the genus Xestospongia. Ichiba, T. Sakai, R. Kohmoto, S. and Saucy, G. Tetrahedron Lett. 1988, 29, 3083. 

Calcul, L, Longeon, A., A1 Mourabit, A., Guyot, M., and Bourguet-Kondradd, M.-L. (2003) Novel alkaloids of the aaptamine class from an Indonesian marine sponge of the genus Xestospongia. Tetrahedron, 59, 6539-6544. 

Iguchi, K, Fujita, M., Nagaoka, H., Mitome, H., and Yamada, Y (1993b) Aragusterol A, a potent antitumor marine sterol from the Okinawan marine sponge of the genus Xestospongia. Tetrahedron Lett., 34, 6277-6280. 

Longeon, A., Copp, B.R., Roue, M., Dubois, J., Valentin, A., Petek, S Debitus, C and Bourguet-Kondracki, M.-L. (2010) New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia. Bioorg. Med. Chem., 18, 6006-6011. 

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