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Xenobiotics response elements

Rushmore, T.H. and Pickett, C.B. (1990) Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants. Journal of Biological Chemistry, 265, 14648-14653. [Pg.315]

Yueh, M.F., Huang, Y.H., Hiller, A., Chen, S., Nguyen, N. and Tukey, R.H. (2003) Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1. Journal of Biological Chemistry, 278, 15001-15006. [Pg.316]

Emi, Y., Ikushiro, S. and Iyanagi, T. (1996) Xenobiotic responsive element-mediated transcriptional activation in the UDP-glucuronosyltransferase family 1 gene complex. Journal of Biological Chemistry, 271, 3952-3958. [Pg.316]

Figure 2.9. Luciferase reporter gene assay/promoter deletion analysis. Cells are transfected with the CYP1A1 promoter reporter (luciferase) constructs in which the promoter region is increasing deleted. The cells are then treated with benzo[a]pyrene (an inducer of CYP1A1), and cells are harvested 24-48hr later and luciferase activity is measured. Promoter deletion analysis revealed enhancer element between -1140 and -1029. Contained within this region is xenobiotic response element (XRE) to which the aryl hydrocarbon receptor (AHR) binds. Figure 2.9. Luciferase reporter gene assay/promoter deletion analysis. Cells are transfected with the CYP1A1 promoter reporter (luciferase) constructs in which the promoter region is increasing deleted. The cells are then treated with benzo[a]pyrene (an inducer of CYP1A1), and cells are harvested 24-48hr later and luciferase activity is measured. Promoter deletion analysis revealed enhancer element between -1140 and -1029. Contained within this region is xenobiotic response element (XRE) to which the aryl hydrocarbon receptor (AHR) binds.
The aryl hydrocarbon receptor (ARH-R or dioxin receptor) is activated by xenobiotics such as 2,3,7,8-tetrachlorodibenzo-j6-dioxin with resultant adverse effects. The activated receptor binds to a xenobiotic-responsive element with the consequent activation of the transcription of particular genes. Cell cycle progression is inhibited by naturally occurring and synthetic flavonoids at concentrations at which they act as agonists of the ARH-R. [Pg.453]

Table 7.2 A partial list of genes containing an antioxidant response element (ARE) or a xenobiotic response element (XRE). More complete lists are reviewed in 60, 61. Table 7.2 A partial list of genes containing an antioxidant response element (ARE) or a xenobiotic response element (XRE). More complete lists are reviewed in 60, 61.
Rushmore TH, King RG, Paulson KE, Pickett CB. 1990. Regulation of glutathione S-transferase Ya subunit gene expression identification of a unique xenobiotic responsive element controlling inducible expression by planar aromatic... [Pg.254]

Lewis, N., T.D. Williams and K. Chipman. Functional analysis of xenobiotic response elements (XRES) in CYP 1A of the European Flounder Platichthys flesus). Mar. Environ. Res. 58 101-105, 2004. [Pg.222]

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See also in sourсe #XX -- [ Pg.90 , Pg.91 ]



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