Wrong lock

Misaligned switches are one of the leading causes of train wrecks. The Federal Railroad Administration (FRA) did report that between January 2001 and December 2003, there were 751 incidents in which switches were not aligned properly and 74 incidents in which the switches were not locked. Hand-operated track switches left in the wrong position caused eight other serious train wrecks since the Graniteville incident. Ten people died and more than 600 were injured in these crashes. 

Your participation is strictly voluntary. You have the right to leave the experiment at any time you wish, without any penalty or hard feelings. Such a decision will not influence any other relationship that you may have to the experimenters (Jane Doe) in any way. There are no right or wrong answers in these tests. It is your unique ability to detect odors that we are interested in. After the experiment, your data will be kept in a locked file cabinet. In any electronic records, you will be identified only by a code number. Your personal data will never be displayed in any presentation or publication with your identity revealed by name or initials. 

Note If the bowl hood does not fit into proper position at once, do not force it down (for instance by screwing on the large lock ring), but examine whether some parts have been wrongly fitted. 

Inhibitors are substances that interfere with the way a catalyst works. One way inhibitors can interfere with the catalyst is to provide it with the wrong key. This key fits, just like the reactant fits in the catalyst, but it does not open the lock. When this happens, the catalyst cannot bind to the correct reactant key. Inhibitors can slow down and, sometimes, even stop chemical reactions. 

This is part of the spectrum from 32 transients obtained without use of a lock but after the field sweep was switched off. It was collected during a busy period in the laboratory immediately after a spectrum in which the lines were very sharp. All of the lines in this example spectrum have the same shape. What is wrong ... 

Hair. You must relate the Baphomet to the spirit you wish to invoke, or you might call the wrong one. Fortunately in this case we have a lock of Dolfm s hair. I put it in the small implements drawer for safekeeping. ... 

When one or more lattice parameters are incorrect, one or more calculated Bragg peaks can lock-on to a wrong observed peak, thus leading to a solid false minimum. 

In the simplest case of parallel-group study, a group of patients presenting sequentially are randomized to one of two equally sized treatment groups, until a prospectively determined total number of patients has been recruited. All these patients are followed for a predetermined period of time, or until some end point is achieved. The database is quality assured and locked before the randomization code is broken. The patients are then sorted according to their treatment, the end point measurements are subjected to a statistical test and an interpretation of the effect (or absence thereof) of the drug is made. What could possibly go wrong ... 

Get the dose right Problems readily arise if the development program gets locked into the wrong dose range early on. It is important to titrate dose ranges down to lessen Type A side effects and to make sure that domiciliary patients are not treated with a dose that is appropriate for seriously ill, hospitalized subjects. 

Pressure too low Lower than expected system pressure is caused by leaks (piston seal, column connections, injector), pump malfunctions (lost prime, air bubbles in pump head, vapor lock, faulty check valves,broken piston), or inadequate solvent supply (empty solvent reservoir, plugged solvent sinker, bent solvent lines, or wrong solvent mixture). Problem diagnostics can be made by visual inspection for leaks and by monitoring the pressure reading of the pump. 

For solvents or reagents delivered in bulk vessels (e.g., tanker trucks), a procedural or physical system, such as valve locking or unique couplings, should be used to prevent accidental discharge of the solvent into the wrong storage tank. 

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