With potassium fluoride, inhibition

Milatovic, D., Johnson, M.K. (1993). Reactivation of phosphor-amidated acetylcholinesterase and neuropathy target esterase hy treatment of inhibited enzyme with potassium fluoride. Chem. Biol. Interact. 87 425-30. 

Fluorophosphinenickel(O) complexes can be formed by reaction of the corresponding chloro-phosphine complexes with potassium fluorosulfinate (equations 9 and 10).1718 The metal inhibits oxidation of the ligand to the phosphinic fluoride, a reaction that occurs readily to the free ligand. 

Reactions on or close to solid surfaces maybe inhibited by deposition ofinsoluble or poorly soluble products on the reactant surface, a phenomenon referred to as overgrowth. Examples include the reaction of amines with chloranil [7], the diazotisation of poorly soluble aromatic amines in which the product diazonium salt is also insoluble and halogen exchange reactions of chloroaromatic compounds using potassium fluoride in dipolar aprotic solvents where the potassium chloride product may coat the potassium fluoride [8]. 

Several agents deUvered via toothpaste inhibit the accumulation of dental calculus. Pyrophosphate salts, with or without a methoxyethylene—maleic acid copolymer, and zinc salts have given positive results in clinical trials (5). Pyrophosphates were added as potassium or sodium pyrophosphate or mixtures at a level of about 2—6%. The zinc salt was zinc citrate [546-46-3] (0.5—2.0%) or zinc chloride [7646-85-7] (2.0%). The products all contained fluoride in addition to the calculus inhibitor. The anticaries activity of the fluoride was not compromised (6). 

ANILINE (62-53-3) Combustible liquid (flash point 158°F/70°C). Unless inhibited (usually by methanol), readily able to polymerize. Violent reaction, including the possibility of fire, explosion, and the formation of heat- or shock-sensitive compounds may result from contact with acetic anhydride, benzene diazonium-2-carboxylate, aldehydes, alkalis, benzenamine hydrochloride, boron trichloride, l-bromo-2,5-pyrrolidinedione, chlorosulfonic acid, dibenzoyl peroxide, fluorine nitrate, halogens, hydrogen peroxide, isocyanates, oleum, oxidizers, organic anhydrides, ozone, perchloryl fluoride, perchromates, potassium peroxide, P-propiolactone, sodium peroxide, strong acids, trichloromelamine. Strong reaction with toluene diisocyanate. Reacts with alkaline earth and alkali metals. Attacks some plastics, rubber, and coatings. Incompatible with copper and copper alloys. 

Enzyme inhibitors are of various types. For example, we can distinguish between irreversible and reversible inhibition. Sometimes an inhibitor reacts so strongly with the active center of an enzyme that the process cannot easily be reversed. Diisopropylfluorophosphate (DFP), for example, undergoes an irreversible reaction with the active centers of certain enzymes, with the liberation of hydrogen fluoride. One of the enzymes with which it reacts is cholinesterase, which is responsible for the functioning of the nerves. As a result DFP is a very powerful nerve gas. Poisons like potassium cyanide exert their action by the irreversible inhibition of enzymes which catalyze oxidative reactions. 

The overall intake of fluorine by adults lies within the range of 0.2 to 2 mg fluorine per day, and is dependent upon the diet (Pendrys 2001). The fraction of fluorine supplied to the body with water is 50-70% in humans and 30-50% in animals. Potassium and sodium fluorides are absorbed in the mouth cavity, and mainly also in the stomach (35%) and intestine (65%). Less-soluble salts (CaFj) are less digestible (up to 62%). Fluorine absorption in animals is inhibited by Ca and Mg salts and phosphates. Likewise, aluminum hydroxide used in medical practice reduces fluorine... 

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