Wilms prognostic factors

This pediatric cancer stands as an example of how cooperative group studies (NWTS and SIOP) have been able to integrate both chemotherapy and radiation into standard therapy while minimizing side-effects and dramatically improving cure rates as seen in the improvement of the 5-yr relative survival rates from 74% in 1974-1976 to 93% in 1989-1996 (60). The fifth NWTS trial began in 1995 and is expected to continue until 2003 (see Table 5) (60). This study will search for biological prognostic factors and examine the rates of cancer and birth defects in children born to survivors of Wilms tumor. 

Grundy P, Breslow N, Green DM et al (1989) Prognostic factors for children with recurrent Wilms tumor results from the Second and Third National Wilms Tumor Study. J Clin Oncol 7(5) 638-647 Grundy P, Perlman E, Rosen NS et al (2005) Current issues in Wilms tumor management. Curr Probl Cancer 29(5) 223-260... 

Grundy PE, Breslow NE, Li S et al (2005) Loss of heterozygosity for chromosomes Ip and 16q is an adverse prognostic factor in favorable histology Wilms tumor a report from the National Wilms Tumor Study Group. J Clin Oncol 23(29) 7312-7321... 

Ng YY, Healy JC, Vincent JM et al (1994) The radiology of non-Hodgkin s lymphoma in childhood a review of 80 cases. Clin Radiol 49(9) 594-600 Ora I, van Tinteren H, Bergeron C et al (2007) Progression of localised Wilms tumour during preoperative chemotherapy is an independent prognostic factor a report from the SIOP 93-01 nephroblastoma trial and study. Eur J Cancer 43(1) 131-136... 

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