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What Is DNA

Many human diseases are caused when certain proteins are either over- or underexpressed. Eor example, breast cancer can be induced by overexpressing certain cellular oncogenes within mammary tissue. To study the disease, researchers produce a line of transgenic mice that synthesize an abnormal amount of the same protein. This leads to symptoms of the disease in mice that are similar to what is found in humans. A protein can be overexpressed by inserting a DNA constmct with a strong promotor. Conversely, underexpression of a protein can be achieved by inserting a DNA constmct that makes antisense RNA. This latter blocks protein synthesis because the antisense RNA binds and inactivates the sense mRNA that codes for the protein. Once a line of mice is developed, treatments are studied in mice before these therapies are appHed to humans. [Pg.242]

Adhering to the convention of writing nucleotide sequences in the 5 o direction, what is the nucleotide sequence of the DNA strand that is complementary to d-ATCGCAACTGTCACTA ... [Pg.354]

UACGGUCUAAGCUGA. What is the corresponding nucleotide sequence (5 —> 3 ) of the template strand in a DNA duplex that might be introduced into these cells so that an antisense RNA could be transcribed from it ... [Pg.355]

A 41.5-nm-long duplex DNA molecule in the B-conformation adopts the A-conformation upon dehydration. How long is it now What is its approximate number of base pairs ... [Pg.392]

A relaxed, circular, double-stranded DNA molecule (1600 bp) is in a solution where conditions favor 10 bp per turn. What is the value of Lq for this DNA molecule Suppose DNA gyrase introduces 12 negative snpercoils into this molecule. What are the values of L, W, and T now What is the snperhelical density, cr ... [Pg.392]

What is the base sequence in the original DNA strand on which the mRNA sequence 1 in Problem 28.9 was made ... [Pg.1112]

The average molar mass of a hydrogen-bonded pair of nucleotides in a DNA molecule is 625 g-mol Each successive pair is found at a distance of 340 pm along the chain. If the total length of one strand of a DNA molecule is 0.299 m, what is the molar mass of the molecule ... [Pg.901]

C13-0074. One strand of DNA contains the base sequence A-T-C. What is the base sequence of the... [Pg.964]

Elephantopus mollis is interesting because it elaborates a series of cytotoxic antitumor germacranolides including molephantinin and phantomolin, which are cytotoxic in vitro and in vivo against Ehrlich ascites carcinoma and Walker 256 carcinosarcoma in rodents (104,105). Molephantinin mitigates DNA and protein synthesis in Ehrlich ascites carcinoma cells and DNA synthesis. What is the activity of molephantinin on apoptosis (106)1... [Pg.217]

See other pages where What Is DNA is mentioned: [Pg.12]    [Pg.25]    [Pg.15]    [Pg.12]    [Pg.709]    [Pg.65]    [Pg.38]    [Pg.40]    [Pg.12]    [Pg.25]    [Pg.15]    [Pg.12]    [Pg.709]    [Pg.65]    [Pg.38]    [Pg.40]    [Pg.1167]    [Pg.1172]    [Pg.447]    [Pg.106]    [Pg.142]    [Pg.1167]    [Pg.1172]    [Pg.32]    [Pg.32]    [Pg.392]    [Pg.392]    [Pg.30]    [Pg.1]    [Pg.778]    [Pg.1165]    [Pg.420]    [Pg.97]    [Pg.943]    [Pg.964]    [Pg.964]    [Pg.312]    [Pg.359]    [Pg.33]    [Pg.110]    [Pg.119]    [Pg.158]    [Pg.2]    [Pg.370]    [Pg.371]    [Pg.5]    [Pg.119]    [Pg.200]    [Pg.289]    [Pg.299]   


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