Weight dose calculation

The ratios of molecular weights for these ethyl homologues, 314 for the phosphate (CEY-19), the same for the sulfate (by the way, it s not yet explored in man, to my knowledge), 276 for the acetate and 234 for the free phenol (CZ-74), all fall into a pretty narrow range, from about 4 to 3. So, the weight of the ester component in the actual molecule being considered is a relatively minor factor in the dose calculation. I am at peace with the hypothesis that all four compounds are interchangeable in potency. 

DOSE CALCULATION BY BODY WEIGHT AND SURFACE AREA... 

The user enters the proposed dose of the active ingredient and a target tablet weight is calculated using both a formula determined from an extensive study of previously successful... 

Benchmark-dose calculations for quantitative outcomes (e.g., birth weight or IQ) are more complicated than those for quantal responses, such as presence or absence of a defect. Although Crump (1984) discussed how to calculate a BMD for a quantitative outcome. Gay lor and Slikker (1992) were the first to develop the approach in any detail. Their first step is to fit a regression model characterizing the mean of the outcome of interest as a function of dose and assuming that the data are normally distributed. The next step is to specify a cutoff to define values... 

If patient is overweight, use ideal body weight to calculate cornstarch dose... 

To be useful for the purposes of dose calculations, measurements of food contamination should relate to the edible portions, not to the entire organism or plant, and it should also be made clear whether the results are on the basis of wet weight or dry weight. The dose calculations made on the basis of the measurements of food contamination should use an average contamination level derived from at least several representative samples. Seasonal crops should be sampled near the time of harvest. Dose calculations should be made on the basis of measurements of the contamination of only those species that are actually consumed by individuals of the critical groups. 

Doses calculated as mass-weighted average to upper and lower large intestine =... 

The acute toxicity of MSG is low (31) the oral LD q for humans, calculated on the basis of doses a dministered in different ways to various animals, would represent a single dose greater than 1 kg for a person weighing 70 kg. In contrast, the oral LD q for sodium chloride in rats is 3.75 g/kg body weight (32). 

The inhalation RfD is derived from the NOAEL by applying uncertainty factors similar to those listed above for oral RfDs. A UF of 10 is used when e.Ktrapolating from animals to humans in addition to the calculation of the human equivalent dose, to account for interspecific variability in sensitivity to the to. icant. The resulting RfD value for inhalation c. posure is generally reported as a concentration in air in mg/m for continuous, 24 hour/day c. posurc, although it may be reported as a corresponding inhaled intake (in mg/kg-day). A human body weight of 70 kg and an inhalation rate of 20 nv /day are used to convert between an inhaled intake e.xprcsscd in units of mg/kg-day and a concentration in air e. pressed in mg/m. ... 

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