Watson, James research

FIGURE 28 2 Molecular modeling—1953 style James Watson (left) and Francis Crick (right) with their DNA model A Barrington Brown/Science Source Photo Researchers Inc... 

One year later, 22-year-old James Watson completed his Ph.D. studies on bacterial viruses at Indiana University and began postdoctoral research in biochemistry in Copenhagen. After a year at Copenhagen, Watson decided Cambridge was the place to be. 

Francis Crick and James Watson point out features of their model for the strueture of DNA. A. Barrington Brown/Soionoo Sonroo/Photo Researchers Inc.)... 

Two major discoveries in 1953 were of crucial importance in the history of biochemistry. In that year James D. Watson and Francis Crick deduced the double-helical structure of DNA and proposed a structural basis for its precise replication (Chapter 8). Their proposal illuminated the molecular reality behind the idea of a gene. In that same year, Frederick Sanger worked out the sequence of amino acid residues in the polypeptide chains of the hormone insulin (Fig. 3-24), surprising many researchers who had long thought that elucidation of the amino acid sequence of a polypeptide would be a hopelessly difficult task. It quickly became evident that the nucleotide sequence in DNA and the amino acid sequence in proteins were somehow related. Barely a decade after these discoveries, the role of the nucleotide... 

Creation of the National Center for Human Genome Research, headed by James Watson, which will oversee the 3 billion U.S. effort to map and sequence all human DNA by 2005,... 

In 1951. James Watson, an American biologist, joined Crick s research. Together they pioneered a new era in science when they proposed lhal the molecular structure of DNA was a double spiral helical chain in a paper published in the sciemific journal. Nature in 1953. This astonishing work was done by Watson, just 24 years uld. and Crick who had not ycl even finished his PhD. In 1962. Crick and Watson shared the Nobel Prize in physiology/medicine for contributions in discovering ihe molecular structure of DNA. Crick continued his studies with DNA as Director of Cambridge University s Molecular Biology Laboratory. 

James Heath is currently professor of chemistry at the University of California, Los Angeles, and director of the California NanoSystems Institute, formed by California Governor Grey Davis in December 2000. He was previously a research staff member at the IBM T. J. Watson Research Labs. 

Bankston, J. Francis Crick and James Watson Pioneers in DNA Research. Hockessin, Del. Mitchell Lane Publishers, 2002. 

Todd s research provided the knowledge of how the nucleotides are linked in DNA and RNA and thus it belongs to the basis of James D. Watson s (b.1928) and Francis H. Crick s (b.1916) work on the structure of DNA, the double helix. In addition, his work on coenzymes opened new vistas for the understanding and manipulation of many biochemical processes and thus contributed fundamentally to concepts that soon would become of use in medicinal chemistry. 

Largely because of advances in biotechnology, the initial working draft of the human genome sequence was completed in 2000, well ahead of schedule. In April of 2003,50 years after James Watson and Francis Crick described the double-helix structure of DNA and over 2 years ahead of schedule, researchers announced the completion of the Human Genome Project. The final version contains 99% of the gene-containing sequence, with 99.9% accuracy. 

When James Watson (left) and Francis Crick discovered the structure of DNA in 1953 using Rosalind Franklin s data, they were research students at the Henry Cavendish Laboratory of Cambridge University. 

After the war Bragg estabfished at the Cavendish Laboratory, with funding from the Medical Research Cotmcil, a unit for the study of molecular structure of biological systems. It was here in 1953 that Francis Crick (whom Bragg did not like) and James Watson determined the double helical structure of DNA. At the start of 1954 Bragg moved to the Royal Institution to... 

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