Water solubility, polymer-ferrocene conjugates

Swarts JC, Neuse EW, Lamprecht GJ (1994) Synthesis and characterization of water-soluble polyaspartamide-ferrocene conjugates for biomedical applications. J Inorg Organomet Polym 4 143-153... 

Polymer bound diaminedichloroplatinum complexes for cancer treatment are briefly discussed. Organoiron compounds of the ferrocene type are also mentioned. A series of water-soluble ferrocene conjugates are presented in which ferrocenylbutanoic acid is reversibly polymer-bound by coupling with pendant amino groups. 43 refs. SOUTH AFRICA Accession no. 702994... 

The same papei describes a conjugate derived from a dihydroxyl-fimctional-ized carrier prepared by an ester-amine polycondensation process from diethyl tartrate and 4,7,10-trioxa-l,13-tridecanediamine. With 1.8 mol of ferrocenylation agent used in the feed for every carrier base mole, the water-soluble product polymer 27 is obtained in a composition corresponding to x/y=4 (Scheme 16). For all conjugates here described the x y ratios, determined by NMR spectroscopy, reflect ferrocene contents of approximately 10-25 mol%, a range considered convenient for biomedical applications. 

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