Water in THF

Many properties of TA mixtures show extrema, e.g. the viscosity (Hayduk et al., 1973) and the activity of water in THF +... 

Cool the reaction mixture to room temperature, add 1.0 M water in THF (1 mL, 1 mmol) and stir overnight. 

The hexanuclear organogallium oxide fluoride, Mes6Ga604F4 (Mes = mesitylene) has been prepared by the reaction of Mes2GaF with water in THF at ambient temperature [14]. The structure of Mes6Ga604F4, which crystallizes with a mole ofTHF, is a distorted octahedron of Ga atoms in which all eight faces are capped by O/F... 

Water in THF is the second most important problem as it makes polymerization impossible. The vapor/liquid equilibrium diagram of the THF/water system at atmospheric pressure is shown in Figure 95. 

In another example of the use of the Staudinger reduction toward the synthesis of medicinally active compounds, Danishefsky s group treated advanced intermediate 57 with trimethylphosphine and water in THF to afford epothilone analog 58 in 79% yield. This... 

Ancillary reagents 3% TCA in methylene chloride (ABI) cap B 16% //-methyl imidazole in THF (ABI) cap A 10% acetic anhydride, 10% 2,6-lutidine in THF (ABI) 16.9 mM h, 49 mM pyridine, 9% water in THF (Perseptive) Burdick Jackson (Muskegon, MI) synthesis grade acetonitrile. A choice of 5-ethylthio-l-Jf-tetrazole solution (0.25 M in acetonitrile), prepared from the solid obtained from American International Chemical (Natick, MA), or 4,5-dicyanoimi-dazole solution (0.5 M in acetonitrile), prepared from the solid obtained from Nexstar Technology Products (Boulder, CO) or l-H-tetrazole solution (0.45 M in acetonitrile) obtained from Glen Research (Sterling, VA), may be used for RNA synthesis. 

Oxidative addition of water to iridium(I) has also been known [185], In this reaction, reaction of [Ir(PMe3)4]+[PF6] with water in THF gave a rare mononuclear hydroxo complex c/5-[Ir(H)(OH)(PMe3)4] [PF6] in high yield. A neutral iridium(I) complex IrCl(dmso)3 is recently reported to show high activity toward oxidative addition of water [186],... 

However it is alternatively allowed the preparation of porous films under dry conditions by introducing water directly into polymer solution by creation of homogeneous emulsions [62]. It is also reported the addition of certain amount of water in THF solution, a water miscible solvent [63]. 

Polyethylene glycol-salen-Co-OAc (Scheme 140) were applied in the HKR of several terminal epoxides with a catalyst loading of 0.5 mol% using 0.55 equiv. of water in THF. A positive dendritic effect was observed the dendritic backbone was supposed to increase the intramolecular cooperation between Co active site by bringing the reactive site of the reactant... 

Figure 12. Hammett op plot for hydrolysis of substituted 1,1 -diphenyl-uranocenes in IM water in THF at 25 C (Ref. 73).

While the moisture absorption of PECA is minimal, the effect of water on the polymer is profound, particularly at pH greater than 7. PECA is sensitive to chain degradation by even weakly basic reagents. For example, 1% of water in THF caused a 50% reduction in the intrinsic viscosity of poly-M-butyl cyanoacrylate in 3 h at 60°C. A probable sequence for the degradation of polycyanoacrylates caused by aqueous base is shown in Scheme 2. 

As a result of the multiple coordination, the N—N length (1.301(12) A) is considerably long, being intermediate between that for azo (— N= N—) and hydrazo (> N—N <) compounds. Treatment of solutions of 23 in diglyme with dry HCl results in loss of most of the bound N2. However, reaction of 23 with water in THF at 23 °C converts over 90% of the ligated N2 to ammonia (mainly) and hydrazine. ... 

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