Wasp venom, mastoparan

Katsu T, Kuroko M, Morikawa T, Sanchika K, Yamanaka H, Shinoda S, Fujita Y. Interaction of wasp venom mastoparan with biomembranes. Biochim Biophys Acta 1990 1027 185-190. Nicas Tl, Hancock REW. Outer membrane protein HI of Pseudbtnoiuu aetmmosa Involvement in adaptive and mutational resistance to cthylenediaminetetraacetate, polymixin B, and gentamicin. ] Bacieriol 1980 143 872. 

Aminomethyl-3-nitrobenzoylpolyethyleneglycols are another class of photosensitive soluble polymeric supports designed for the liquid phase synthesis of protected peptide amides 192,193) (scheme 8). These supports have been very recently used for efficient synthesis of three biologically active 14-peptideamides corresponding to the wasp venom peptides, mastoparan, mastoparan X and Polistes mastoparan 198). 

Histamine release from mast cells can be caused by a wide variety of basic substances, including mediators such as substance P, bradykinin and venoms such as mastoparan (from wasp venom). It is thought that this interaction involving endogenous mediators is a normal part of pathophysiology involved, for instance, in the triple response in skin. It has been proposed that the non-receptor-... 

Mandaratoxln. A wasp venom from Vespa manda-rina structurally related to mastoparan. 

Mastoparans. M. 1 C7oH 3,N 0,5, Mr 1478.93, colorless powder, a peptide from the wasp venom of Ves-pula lewisii M. X C73H,26N2oO,5S, Mr 1556.0 from Vespa xanthoptera with the structural formulae ... 

In a related paper, Ikeda et al. has presented a combined use of replica-exchange MD and solid-state MAS NMR spectral simulations for determining the structure and orientation of membrane-bound peptide." First, an ensemble of low energy structures of mastoparan-X, a wasp venom peptide, in lipid bilayers was generated by replica exchange molecular dynamics (REMD) simulation with the implicit membrane/solvent model. Next, peptide structures compatible with experimental chemical shifts of C,, Cp and C carbons were selected from the ensemble. Chemical shifts of C, alone were sufficient for the selection with backbone rmsd s of 0.8 A from the experimentally determined structure. The dipolar couplings between the peptide protons and lipid nuclei were obtained from the C-... 

Higashijima, T., Wakamatsu, K., Takemitsu, M., Fujino, M., Nakajima, T., and Miyazawa, T., 1983, Conformational change of mastoparan from wasp venom on binding with phospholipid membrane. FEBS Lett. 152 227-230. 

Mastoparan. Wasps produce a wide variety of toxic peptides (202) that includes mastoparan, a 14-residue peptide isolated from the venom of Paravespula lewisii. Mastoparan stimulates the degranulation of mast cells,... 

Mastoparan, INLKALAALA KKILa, a 14-peptide amide found in the venom of wasps. Mastoparan degranulates mast cells and induces the release of catecholamines and serotonin from adrenal chromaffin cells or platelets. Mastoparan C, [Leu , Val ]mastoparan, and crabolin... 

Recent discoveries of biologically active peptides in venoms, such as mastoparan from the Japanese hornet or vespulakinin from wasps, suggest that many more such interesting compounds should be found in various insects in the not too distant future. 

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