W-Hexyl alcohol

Fig. 26. Plot of parameter C2 versus pressure for w-hexyl alcohol dehydration, Eqs. (80 and (81).

With -propyl alcohol, some syn addition occurs and the products 94 and 95 (R = Pr) are formed in the ratio 87 13. This same ratio prevails approximately for the addition of the isomeric butyl alcohols, but substantially larger proportions of syn addition products are formed with -pentyl and w-hexyl alcohols. For example, with w-hexyl alcohol the ratio of 94 to 95 (R = n-Hex) is 53 47" . 

See Methyl-w>hexyl Alcohol. 2-Methylhexanol-2 (DirnethyUnUylcarbirial, 2 hydroxyisoheptane, iioheptanoU2)... 

M-Hexyl alcohol has been prepared by the reduction of ethyl caproate by means of sodium and absolute alcohoB alone or in anhydrous ammonia solution by the reduction of -caproamide by means of sodium and absolute alcohol by the reduction of -caproaldehyde by means of sodium amalgam in dilute sulfuric acid and by means of living yeast, It has also been produced by the action of nitrous acid upon w-hexylamine by the action of sodium upon a mixture of ethyl alcohol and M-butyl alcohol ... 

Tri-n-hexylstibine, (CeHi3)3Sb,2 boils at 190° C. at 10 mm. with partial decomposition and hberation of antimony. The distillate has a density of about 1 15 at 25° C. The odour resembles that of 2-hexyl alcohol. w-Do decane is formed as a by-product in the preparation. 

Definition Ester of a branched chain hexyl alcohol and lauric acid Empiricai C18H36O2 Formuia CH3(CH2)ioCOOC6Hi3 Uses Emollient in cosmetics Manuf./Distrib. A E Connock http //www.connock.co.uk, ChemService http //www. chemservice. com Isohexyl neopentanoate CAS 131141-70-3 Synonyms 2-Ethyl butyl 2,2-dimethylpropanoate Hexyl 2,2-dimethylpropanoate Neopentanoic acid, isohexyl ester Propanoic acid, 2,2-dimethyl-, 2-ethylbutyl ester Empiricai C11H22O2 Properties M.w. 186.33 Uses Emollient, moisturizer, penetrant, skin conditioner in cosmetics constituent in aroma chemicals... 

FIGURE 5.21 High-speed isothermal separation of a 20-component mixture using a pressure-tunable column ensemble. The plots of band position versus time were obtained from the retention factors for the mixture components on the two separate colimms along with the column dimensions and the inlet, outlet and junction point pressures. A window diagram was used to determine the junction point pressure for the complete separation of the first 14 components. Compounds are 1, n-pentane 2, methyl alcohol 3, 2,2-dimethylbntane 4, 1,1,1-trichloroethane 5, cyclopentane 6, w-hexane 7, w-propyl alcohol 8, cyclohexane 9, benzene 10, n-heptane 11, l,2-dichloropropane 12, toluene 13, n-bntyl alcohol 14, w-octane 15, 2-hexyl alcohol 16, n-pentyl alcohol 17, ethylbenzene 18, m-xylene 19, w-nonane 20, o-xylene. 

Alkyl halides are even less reactive than acyl halides, as indicated by the compilation of reaction rates of thiolate anions with various types of alkyl halides (282). Nevertheless, potentially useful affinity labels have been synthesized with alkyl halide substituents and have been shown to specifically inactivate several enzymes, albeit slowly the low reactivity of the alkyl halides may minimize nonspecific reaction. Adenosine 5 -(2-bromoethyl)phosphate has been characterized and reported to inactivate NAD -dependent isocitrate dehydrogenase (283). The 2 - and 3 -(2-bromoethyl)-AMP labels have also been synthesized, and model reactions of the bromoethyl-AMPs with cysteine, lysine, histidine, and tyrosine have been studied (284). More recently, esters of adenosine 5 -monophosphate have been prepared with ethyl, propyl, or hexyl moieties and bromo or chloro substituents at the w position (285). Yeast alcohol dehydrogenase exhibited enhanced inactivation by the hexyl derivative, but inactivation rates of other dehydrogenases were unremarkable. Two iodopropyl derivatives of cAMP have been described, namely, 1, A -(3-iodopropyleno)adenosine 3, 5 -cyclic monophosphate and 3 -0-(2-iodo-3-hydroxypropyl)adenosine 3, 5 -cyclic monophosphate the latter inactivates cAMP phosphodiesterase from human platelets, with a pseudo-first-order rate constant of 0.147 hr" (286). 

Yields of the primary alkyl acrylates vary somewhat, owing to occasional losses through formation of pol3mier, but are usually in the range of 85-99%. Some secondary alcohols react very slOwly, others readily. The method has been applied to more than fifty alcohols, some of which (with percentage yields) are listed below ethyl, 99% isopropyl, 37% w-amyl, 87% isoamyl, 95% -hexyl, 99% 4-methyl-2-pentyl, 95% 2-ethylhexyl, 95% capryl, 80% lauryl, 92% myristyl, 90% aUyl, 70% fur-furyl, 86% citronellyl, 91% cydohexyl, 93% benzyl, 81% 0-ethoxyethyl, 99% /3-((3-phenoxyethoxy) ethyl (from diethylene glycol monophenyl ether), 88%. 

In 1941, Adams and Whitehill reported that 1,1, 4,4 -bis (hexamethylenedioxy)-dibenzene (a cyclic polyether containing four oxygen atoms in the ring) was successfully synthesized by the direct condensation of bis (w-bromo-n-hexyl) ether of hydro-quinone and hydroquinone in amyl alcohol with dry potassium carbonate. The yield of the product was about 15 percent. Since then, numerous papers prior to 1967 have been published concerning the synthesis of cyclic polyethers. Table I lists several of the papers and authors that have contributed to the synthesis of this product.j11>12,13,14... 

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