Vulvar cancer chemoradiation

A number of phase I and II trials of chemoradiation for gynecologic malignancies have included patients with vaginal or vulvar cancer, but the number of patients with these rare malignancies has been too small to support large randomized trials. 

In general, phase II trials of chemoradiation for vulvar cancer have yielded encouraging response rates (Table 4). Most studies of cisplatin or mitomycin C plus fluorouracil have yielded vulvar local control rates of better than 50% in women with advanced... 

Moore DH, Thomas GM, Montana GS, et al. Preoperative chemoradiation for advanced vulvar cancer a phase II study of the Gynecologic Oncology Group. Int J Radiat Oncol Biol Phys 1998 42 79-85. 

Leiserowitz GS, Russell AH, Kinney WK, et al. Prophylactic chemoradiation of inguinofemoral lymph nodes in patients with locally extensive vulvar cancer. Gynecol Oncol 1997 66 509-514. 

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