Vomiting mechanisms that trigger

Mechanism of Action A 5-HT3-receptor antagonist that acts centrally in the chemore-ceptor trigger zone and peripherally at the vagal nerve terminals. Therapeutic Effect Prevents nausea and vomiting. 

Mechanism of Action A dopamine receptor antagonist that stimulates motility of the upper G1 tract and decreases reflux into the esophagus. Also raises the threshold of activity in the chemoreceptor trigger zone. Therapeutic Effect Accelerates intestinal transit and gastric emptying relieves nausea and vomiting. 

Mechanism of Action A phenothiazine that acts as an antihistamine, antiemetic, and CNS-antipsychotiC typical hypnotic. As an antihistamine, inhibits histamine at histamine receptor sites. As an antiemetic, diminishes vestibular stimulation, depresses labyrinthine function, and acts on the chemoreceptor trigger zone. As a sedative-hypnotic, produces CNS depression by decreasing stimulation to the brainstem reticular formation. Therapeutic Effect Prevents allergic responses mediated by histamine, such as rhinitis, urticaria, and pruritus. Prevents and relieves nausea and vomiting. Pharmacokinetics ... 

Mechanism of Action A piperazine phenothiazine that acts centrally to block dopamine receptors in chemoreceptor trigger zone in central nervous system (CNS). Tiicr-apeutic Effect Relieves nausea and vomiting. 

Mechanism of Action An anticholinergic that acts at the chemoreceptor trigger zone in the medulla oblongata. Therapeutic Effect Relieves nausea and vomiting. Pharmacokinetics ... 

Ethanol, CH3-CH2-OH, is a low-molecular-weight hydrocarbon that is rapidly absorbed across both the gastric mucosa and the small intestines, reaching a blood peak concentration 20-60 minutes after ingestion. Ethanol is a toxin too high a dose triggers a primary defence mechanism, namely vomiting. 

Some trichothecene-induced effects may be due to neurotransmitter alteration in the central nervous system. Emesis or vomiting, which occurs with many of the trichothecenes when given at high doses, has been attributed to the stimulation of the chemoreceptor trigger zone in the area postrema of the medulla oblongata. However, studies with T-2 toxin in cats indicated that other mechanisms, such as the neural afferent pathways from the abdomen, implicated in radiation-induced emesis, may also be involved (Borison and Goodheart, 1989). DON alters serotonin activity in the central nervous system of swine which is important in... 

---