Vogel conflict test

These models are classified into two major groups those based on unconditioned behavior and those based on conditioned behavior. The former tests employ responses controlled ty operant conditioning procedures, and are typified by the traditional Geller-Seifter and Vogel conflict tests, whereas the latter models rely on the natural aversive reactions of animals to novel stimuli, such as an unfamiliar environment (elevated plus maze) or another animal (social interaction). Although it is imperative to use a variety of animal models, tests that do not involve unnatural responses or punishment are increasingly favored. 

The anxiolytic activity of rose oil has recently been reported by two groups. In the first smdy, the oil was active in mice using the Geller and Vogel conflict tests. The authors concluded that the active constituents were 2-phenethyl alcohol and citronel-lol. In the second study, inhalation of rose oil to adult male rats (1-5% w/w) produced an anxiolytic effect comparable to diazepam (1 and 2mg/kg, i.p.) in the elevated plus-maze test. ... 

Matsuo M, Kataoka Y, Mataki S, Kato Y, Oi K (1996) Conflict situation increases serotonin release in rat dorsal hippocampus In vivo study with microdialysis and Vogel test. 

Another high affinity partial agonist for the BZD site of the GABAa receptor, compound (27), was as effective as diazepam in increasing the number of shocks taken in the Vogel assay and was similarly active in the Gel-ler-Cook conflict anxiety test. This compound also prevented PTZ-induced seizures in mice and was found to be a partial BZD agonist in vitro. No typical benzodiazepine-like side effects were observed for (27) [66]. 

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