VNTR variable number of tandem

Expansion of repetitive sequences (minisateflites or VNTRs, variable number of tandem repeats) within the DNA... 

VNTRs (variable number of tandem repeats). These polymorphisms are the result of varying numbers of minisatellite repeats in a specific region of a chromosome. The repeat units typically range in size from 20 to 70 bases each. The repeat is flanked on both sides by a restriction site, and variation in the number of repeats produces restriction fragments of varying size. 

ViraferonPeg 468 Viral vector generation 156 Virosomes 1425 Virtron 17, 468 Virus based vector 186 Virus purification 158 Virus safety 1650 Visceral endoderm 294 Viscum album 482 Visudine 1280 VitoTox 1628 Vitravene 24, 633 Vivid screening kit 1613 VNTR (variable number of tandem repeats) marker 77... 

Kasai K, Nakamura Y and White R 1990) Amplification of a variable number of tandem repeats (VNTR) locus (pMCTii8) by the polymerase chain reaction (PCR) and its application to forensic science. ] For Sci 35 1196-1200. 

Ethnic variation in allele frequencies can lead to important differences in disease susceptibility, outcome and drug metabolism [68, 69]. In addition to single nucleotide polymorphisms, variable number of tandem repeat (VNTR) regions have been shown to have functional significance. 

Y. Nakamura, M. Leppert, P. O Connell, R. Wolff, T. Holm, M. Culver, C. Martin, E. Fujimoto, M. Hoff, E. Kumlin, Variable Number of Tandem Repeat (VNTR) Markers for Human Gene Mapping , Science, 235,1616-1622 (1987). 

Nakamura Y, Leppert M, O Connell P, Wolff R, Holm T, Culver M, Martin C, Fujimoto E, Hoff M, Kumlin E, White R. Variable number of tandem repeat (VNTR) markers for human gene mapping. Science 1987 235 1616-1622. 

The different alleles at a minisatellite locus are thought to vary in the number of repeats of the consensus sequence, hence the name variable number of tandem repeats (VNTR) locus.7 For some human VNTR loci... 

Fig. 8. Loss of RFLP heterozygosity in tumor tissue. Hybridization of probe p68RS2.0 for a variable number of tandem repeats (VNTR) marker on chromosome 13 to normal (N) and breast tumor (T) tissue is demonstrated for 7 patients. Note the presence of 2 bands in normal tissue from each patient, but markedly decreased or absent hybridization of either the upper or lower allele in a number of patients, most clearly shown for patients 035 (lower), 090 (upper), 091 (upper), 177 (upper), and 181 (lower). Numbers to the left indicate the size (in kb) of marker fragments. (From Devilee et al. (57), reproduced with permission from Academic Press.)...

In the mid-1980s, these techniques were replaced by direct analysis of the DNA polymorphisms. The first of such techniques, developed by Alec Jeffries utilized multilocus DNA probes. This technique is known as the restriction fragment length polymorphism (RFLP) testing. RFLP techniques are based on variable number of tandem repeats (VNTR), which are sequences of 10 to 60 bp (base pairs) of length, that lie adjacent to each other in the same chromosomal orientation (minisatellites). 

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