Vitro Systems Derived from Estrogen-treated Animals

In Vitro Systems Derived from Estrogen-treated Animals 

An important approach to the location of the sites of action of estrogens has been through the comparison of the metabolism of preparations of target tissues removed from control animals with those taken from animals pretreated with physiological doses of estrogens. 

The profound effects of estrogen, both on the cleavage of. serine to a one-carbon fragment and on the synthesis of serine from formate and gly- 

Interesting effects of estrogen pretreatment upon carbohydrate metabolism in rat liver and the interrelations of estrogen action with adrenocortical secretion and insulin action are discussed by McKerns el al. (1958). These observations should provide additional points of attack for the development of in nlro sterns. 

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VII. In Vitro Systems Derived from Estrogen-treated Animals. 213... 

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