Virulence-Associated Genes

Chiang YL, Lin CH, Yen MY, Su YD, Chen SJ, Chen HF (2009) Innovative antimicrobial susceptibility testing method using surface plasmon resonance. Biosens Bioelectron 24 1905-1910 China B, Pirson V, Mainil J (1996) Typing of bovine attaching and effacing Escherichia coli by multiplex in vitro amplification of virulence-associated genes. Appl Environ Microbiol 62 3462-3465... 

Durand, J.M., Okada, N., Tobe, T., Watar-ai, M., Fukuda, I., Suzuki, T., Nakata, N., Komatsu, K., Yoshikawa, M., Sasakawa, C. vacC, a virulence-associated chromosomal locus of Shigella flexneri, is homologous to tgt, a gene encoding tRNA—guanine transglycosylase (TGT) of Escherichia coli K-12. J. Bacteriol. 1994, 176, 4627-4634. 

Escuyer, V., Duflot, E., Sezer, O., Danchin, A., Mock, M. (1988). Structural homology between virulence-associated bacterial adenylate cyclases. Gene 71 293-8. 

Genes regulated by Fur code for proteins that function in iron transport and iron metabolism under aerobic conditions, iron metabolism is associated with oxidative stress. In addition, some virulence factors are regulated by Fur. Table 3.2 lists examples and functions of Fur- and iron-regulated genes in E. coli, including pathogenic E. coli strains. 

Several PhoP-activated genes encode products that mediate Salmonella LPS modifications and may promote virulence and CAMP resistance (Gunn and Miller, 1996 Guo et al., 1997 Guo et al., 1998). In addition to being able to directly activate genes associated with LPS modification, PhoPQ is also able to indirectly modify LPS by activating a second TCRS called PmrAB (Gunn and Miller, 1996 ... 

Han, W., Liu, B., Cao, B., Beutin, L., Kruger, U., Liu, H., Li, Y., Iiu, Y., Feng, L., Wang, L. DNA microarray-based identification of serogroups and virulence gene patterns of Escherichia coli isolates associated with porcine postweaning diarrhea and edema disease. Appl Environ Microbiol 73 (2007) 4082-4088. 

---