Veterinary biological establishment

Figure 7.9 Outline of requirements for a Veterinary Biologies Establishment License.

The most recently reported UK results on surveillance for veterinary drug residues in meat and animal products show that traces of these compounds can, and sometimes do, arise in food. As all of these compounds are biologically potent in order to be effective in use, it is necessary to ensure that any residual activity in a food product does not present a risk to the consumer. The use of veterinary medicines inevitably leads to the presence of trace residues in food and the purpose of toxicological safety evaluation is to determine at what concentration the residues of a particular compound becomes a cause for concern with regard to human health. Thus, dose-response relationships have to be established and used to determine the concentration of a dmg at which the risks to human health become acceptable and are outweighed by the benefits from the use of the drug. This is in essence the process involved in the setting of Acceptable Daily Intakes (ADIs) and... 

In 1999, the Centers for Disease Control and Prevention (CDC) established the Laboratory Response Network (LRN). The CRN s purpose is to run a network of labs that can respond to biological and chemical terrorism. The LRN has grown to greater than 100 LRN laboratories since it was established. It now includes state and local public health, veterinary, military, and international labs. 

The Federal Food, Drug and Cosmetic Act (FFDCA) places the responsibility for establishing the safety and efl cacy of human and veterinary drugs and devices and the safety of food and color additives on the sponsor of the regulated product. The Public Health Service Act requires that a sponsor establish the safety and efl cacy of biological products. These laws... 

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