Vesicles targeting

Step 5 Vesicle targeting is achieved via members of a family of integral proteins, termed v-SNAREs, that tag the vesicle during its budding. v-SNAREs pair with cognate t-SNAREs in the target membrane to dock the vesicle. 

Sollner, T., Whiteheart, S. W., Brunner, M., Erdjument-Bormage, H., Geromanos, S., Tempst, P. and Rothman, J. E3. SNAP receptors implicated in vesicle targeting and fusion. Nature 362 318-323,199. 

Insertion of recognition groups into vesicle membranes provides ways of performing vesicle targetting [7.51-7.53] (for instance for drug delivery) and of setting up models of cell-cell interactions [7.51, 7.54]. 

Neurotransmitters are released by exocytosis, a process in which neurotransmitter-filled synaptic vesicles fuse with the axonal membrane, releasing their contents into the synaptic cleft. The exocytosis of neurotransmitters from synaptic vesicles involves vesicle-targeting and fusion events similar to those that occur during the intracellular transport of secreted and plasma-membrane proteins (Chapter 17). Two features... 

Sollner, T., et al. SNAP receptors implicated in vesicle targeting and fusion. Nature 362 318-324. 

Vega, I. E., and Hsu, S. (2001). The exocyst complex associates with microtubules to mediate vesicle targeting and neurite outgrowth. J. Neurosci. 21, 3839-3848. 

Pfeffer, S. R. (1999). Transport-vesicle targeting Tethers before SNAREs. Nat. Cell Biol. 1,... 

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