Recognition groups

This chapter will introduce the field of sensors based on molecular imprinted polymers (MIPs). MIPs are highly cross-finked polymers that are formed with the presence of a template molecule (Haupt and Mosbach 2000 Wulff 2002). The removal of the template molecule from the polymer matrix creates a binding cavity that is complementary in size and shape to the template molecule and is fined with appropriately positioned recognition groups (Scheme 15.1). 

A constellation of recognition groups is said to be meaningful when it allows long-distance recognition of the ligand or substrate (see Section 2.3.3). 

Insertion of recognition groups into vesicle membranes provides ways of performing vesicle targetting [7.51-7.53] (for instance for drug delivery) and of setting up models of cell-cell interactions [7.51, 7.54]. 

Homo-assembly of derivatives of the self-complementary recognition group 168 can only yield a linear ribbon or tape structure 179. This is indeed the case, as shown... 

A supramolecular polymer chemistry has developed, concerning polymers of supramolecular nature generated by the self-assembly of monomers interconnected through complementary interaction/recognition groups [18-21]. 

In order to develop small molecules capable of eliciting similar effects as AFC in the pharmacologic inhibition of Icmt, it has thus become evident that specific structural requirements must be observed. Specifically, the isoprenyl motif was identified as a necessary recognition group and the presence of a correct prenyl moiety is a key feature for biological activity. Thus, pharmacophore development for Icmt inhibitors became the focus of several research groups in the coming years. 

Hi. Use of dopant anions containing molecular recognition groups... 

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