Veratrine

Commercial veratrine is a mixture of alkaloids prepared from sabadilla seeds and consists largely of cevadine and veratridine with some cevine. Its manufacture has been described by Schwyzer. Crystalline veratrine was first isolated by G. Merck. Wright and Luff introduced the name cevadine to distinguish this alkaloid from the commercial amorphous mixture known as veratrine. ... 

Jervine has also been recorded from other Veratrum spp., e.g., V. nigrum, V. lobelianum and V. grandiflorum and veratrine-like alkaloids in Zygadenus spp. (p. 779). 

Cevadine, C32H49O9N (crystallised veratrine), was first isolated in a crystalline condition from sabadilla seeds by G. Merek, who called it veratrine, and was subsequently obtained by Schmidt and Koppen,i and by Wright and Luff, whose name cevadine has been generally adopted, though Ahrens suggested that it should be called crystallised veratrine. The yield of total alkaloids from the seeds is said to be from 6 to 7 gm. per kilo, of which 0-8 to 0-9 gm. may be obtained as crystalline cevadine, 0-5 to 0-6 as veratridine and 0-2 to 0-3 as sabadilline. 

Veratridine (amorphous veratrine), CggHgiOuN. This alkaloid, probably identical with Schmidt and Koppen s water-soluble amorphous veratrine and with the amorphous veratrines of Wright and Luffi and G. Merck, was named veratridine by Bosetti. Its isolation from commereial veratrine has been described by Blount.It is a colourless powder, m.p. 160-180°, + 8 0° (EtOH). The sulphate, B. H2SO4.9H2O,... 

Neither the drugs yielding these alkaloids nor the alkaloids themselves are now recognised in the British or United States Pharmacopoeia, but the drugs still appear in non-official publications along with veratrine, which may be either amorphous, i.e., the mixture already referred to, or crystalline, i.e., the alkaloid cevadine. 

Veratrine, commercial, 701 Veratrine (orystallised). iSee Cevadine. Veratrosine, 701, 707 Veratroylbikaconine, 685 Veratroylmethylpseudaconine, 682 Veratroylpseudaconine, 682 Veratroylpseudaconine, 684 Veratroyltropine, see Convolvamine ... 

Vaccine 40 Vaccinines A-B 27 Vasicine 71, 106, 107 Vellosimine 16 Veratrine 11 Villalstonine 30, 55... 

Rhododendron sinensis Sw. Yang Zhi Zu (Chinese rhododendron) (flower) Andromedotoxin, veratrine alkaloids.49 This herb is toxic. Sedative, analgesic, anesthetic in rheumatism. 

Veratridine. An alkaloid neurotoxin purified from veratrine. [McKinney et al. AB 153 33 1986]. 

Veratrine (= mixture of Schoenocaubn offieinak [seed], Cevadine, Cevine, Veratrum viride [root] (Liliaceae)... 

Acepromazine, acetophenazine, adiphenine, azacyclonol, barban, benzilonium, benzyl nicotinate, biperiden, clemastine, clomiphene, cyclothiazide, dextropropoxyphene, dichlorprop, dicophane, diperodon, diphem-anil, diphenidol, emepronium, etenzamide, fenpiprane, flurbiprofen, haloperidol, mepenzolate, methyl-piperidyl benzilate, mexiletine, nadolol, penfluridol, phenaglycodol, phenylbutazone (100°), phosalone, pimozide, pipazethate (100°— red), pipoxolan, pyrrobutamine, rotenone, sotalol (100°), sulindac, veratrine, zimeldine... 

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