Ventilation control reduced sensitivity

The respiratory mechanism for controlling blood pH begins in the brain with respiratory center neurons that are sensitive to blood CO2 levels and pH. A significant increase in the CO2 of arterial blood, or a decrease below about 7.38 of arterial blood pH, causes the breathing to increase both in rate and depth, resulting in hyperventilation. This increased ventilation eliminates more carbon dioxide, reduces carbonic acid and hydrogen-ion concentrations, and increases the blood pH back toward the normal level (see > Figure 15.11). 

Q Implement appropriate controls to prevent exposure. Preventing exposru e to isocyanates is a critical step in eliminating the health hazard. Engineering controls such as closed systems and ventilation should be the principal method for minimizing isocyanate exposvu e in the workplace. Other controls, such as worker isolation and use of personal protective equipment such as respirators and personal protective clothing to prevent dermal exposures may also be necessary. Early recognition of sensitization and prompt and strict elimination of exposures is essential to reduce the risk of long-term or permanent respiratory problems for workers who have become sensitized. 

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