Venous thromboembolism with/without

Table 1 Incidences of venous thromboembolism with and without breast cancer taking various treatments (37) ...

The risks of venous thromboembolism in women with and without breast cancer have been analysed and are summarized in Table 1 (37). In one case tamoxifen was associated with myocardial infarction (38). 

One of the risks associated with use of combined hormonal contraceptives is venous thromboembolism, but in women without other contributing risk factors the risk of thrombosis is less than that observed during pregnancy. The risk of thromboembolism increases with both age and the presence of other risk factors, such as obesity or an immobilizing illness. There is also a small risk of arterial disease, particularly if the woman has a previous history of arterial disease, hypertension, diabetes mellitus or if she is obese. 

A retrospective study of 616 courses of IVlG in 62 patients (43 male, mean age 58.5 years) with neuropathy found thromboembolic complications in seven patients, five (two myocardial infarction, one acute coronary syndrome, one deep venous thrombosis (DVT) without a pulmonary embolus (PE) and one DVT with PE) of which were deemed early occurring within 14 days of treatment. Daily dose of lVIG>35g was correlated with early thromboembolic complication. Independent risk factors for thromboembolic complications included coronary artery disease and current immobility. Thromboembolic complications were significantly increased in patients with four or more of the risks factors listed in Table 1 [79 ]. 

Thromboembolic complications developed in two of 81 patients with Von Willebrand disease treated with a high-purity factor VlllWon Willebrand factor (VWF) concentrate (10). Four cases of venous thrombosis were reported in patients with Von Willebrand disease treated with an intermediate-purity factor VIII/VWF concentrate. Use of pure VWF concentrate without increased factor VlllrC is preferable (11). 

Clinical indications Prophylaxis and treatment of venous thrombosis PE peripheral arterial embolto AF Prevention of DVT and other thromboembolic complications treatment of acute DVT with or without PE Prophylaxis and treatment of venous thrombosis and its extension PE and thromboembolic complications associated with AF... 

---