VEGF Receptor Targeting

Targeting Tumor Blood Vessels With a Toxin Conjugate 

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Antibody targeting Use of mono-and bispecific antibodies to target components of angiogenic blood vessels (e.g., VEGF receptors, endoglin, L19 antigen) to deliver specific angio- and/or tumoricidal activity... 

Shen J, Samul R, Silva RL et al (2006) Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1. Gene Ther 13 (3) 225-234... 

Schlaeppi JM, Wood JM. Targeting vascular endothelial growth factor (VEGF) for anti-tumor therapy, by anti-VEGF neutralizing monoclonal antibodies or by VEGF receptor tyrosine kinase inhibitors. Cancer Metastasis Rev 1999 18 4734-81. 

Witte L, Hicklin DJ, Zhu Z, et al. Monoclonal antibodies targeting the VEGF receptor-2 (Flk-l/KDR) as an anti-angiogenic therapeutic strategy. Cancer Metastasis Rev 1998 17 155-161. 

Demirovic, A. M., Marty, C., Console, S., Zeisberger, S. M., Ruch, C., Jaussi, R., Schwendener, R. A., and Ballmer-Hofer, K. (2005), Targeting human cancer cells with VEGF receptor-2-directed liposomes, Oncol. Rept., 13, 319-324. 

Normalization of tumor vasculature Targeting vascular endothelial growth factor (VEGF) receptors to prune the immature, abnormal blood vessels, so more efficient drug penetration is achieved 147... 

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