Vasopressin model

Saffran, M. Bedra, C. Kumar, G.S. Neckers, D.C. Vasopressin model for the study of effects of additives on the oral and rectal administration of peptide drugs. J. Pharm. Sci. 1988, 77, 33-38. 

Diabetes insipidus occurs with a loss of vasopressin production in the Brattleboro rat model 330 Mutations and knockouts of peptide-processing enzyme genes cause a myriad of physiological problems 330 Neuropeptides play key roles in appetite regulation and obesity 330 Enkephalin knockout mice reach adulthood and are healthy 331 Neuropeptides are crucial to pain perception 331... 

Diabetes insipidus occurs with a loss of vasopressin production in the Brattleboro rat model. In the... 

The neurohormonal model of HF recognizes that an initiating event (e.g., acute MI) leads to decreased cardiac output but that the HF state then becomes a systemic disease whose progression is mediated largely by neurohormones and autocrine/paracrine factors. These substances include angiotensin II, norepinephrine, aldosterone, natriuretic peptides, arginine vasopressin, proinflammatory cytokines (e.g., tumor necrosis factor a, interleukin-6 and interleukin-1 ft), and endothelin-1. 

The mechanism of action of this kappa mediated neuroprotective effect is under investigation. In addition to the diuretic effects mentioned above, it has been shown that CI-977 (11) is inactive in a model of focal brain ischaemia in Brattleboro rats which lack vasopressin and do not exhibit kappa-mediated water diureses [33c]. An alternative mechanism for which there is increasing evidence is an inhibition of excitatory amino-acid release. U-50488 (5) and PD 117302 (12) have been shown to block convulsions in-... 

Arima H, Aguilera G (2000) Vasopressin and oxytocin neurones of hypothalamic surpaop-tic and paraventriciflar nuclei co-express mRNA for type-1 and type-2 corticotropinreleasing hormones receptors. J Neuroendocrinol 12 833-842 Arletti R, Bertolini A (1987) Oxytocin acts as an antidepressant in two animal models of depression. Life Sci 41 1725-1730... 

Ron an PJ, Kramer GL, Petty F (2001) Corticotropin releasing factor and arginine vasopressin effects in the learned helplessness animal model. Soc Neurosci Meeting Abstr 414.20 Rosen JB, Schulkin J (1998) From normal fear to pathological anxiety. Psychol Rev 105 325-350... 

Young LJ (2001) Oxytocin and vasopressin as candidate genes for psychiatric disorders lessons from animal models. Am J Med Genet 105 53-54... 

The mobility of the acyclic terminal tripeptide in lysine vasopressin is larger compared to that in oxytocin, which is coincident with a model suggested from H NMR studies [856]. 

Fig. 72. Wedge-shaped contrast enhancement after the administration of vasopressin in an animal model (p. 73)...

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