Vascular tissue engineering blood vessel structure

Classical synthetic polyesters such as poly(E-caprolactone) (PCL), poly(L-lactic acid) (PLLA), poly(glycolic acid) (PGA), and their copolymers can provide the necessary strength for structural stability, and their scaffolds have been explored for the regeneration of blood vessel substitutes [51-53]. However, they are relatively stiff, nonelastomeric materials and not ideally suited for engineering of soft flexible tissues such as vascular grafts. 

A number of studies have shown that the biodegradable polymers mimic the natural ECM and show a defined structure replicating the in vivo-like vascular structures and can be ideal tools for blood vessel tissue engineering [40]. 

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