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Vascular endothelium-derived growth factor

Malek, A. M., Gibbons, G. H., Dzau, V. J., and Izumo, S. (1993). Fluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor chain in vascular endothelium. J. Clin. Invest. 92, 2013-2021. [Pg.203]

Elevated peripheral arterial resistance is a hallmark of primary hypertension. The increase in peripheral resistance typically observed may be due to a reduction in the arterial lumen size as a result of vascular remodeling. This remodeling, or change in vascular tone, may be modulated by various endothelium-derived vasoactive substances, growth factors, and cytokines. This increase in arterial stiffness or reduced compliance results in the observed increase in systolic blood pressure.9... [Pg.14]

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Vascular growth

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