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Valproic acid dosage

Bowdle TA, Patel IH, Levy RH, el al. Valproic acid dosage and plasma protein binding and clearance. Clin Pharmacol Ther 1980 28 486-492. [Pg.72]

When carbamazepine is administered with primidone, decreased primidone levels and higher carbamazepine serum levels may result. Cimetidine administered with carbamazepine may result in an increase in plasma levels of carbamazepine that can lead to toxicity. Blood levels of lamotrigine increase when the agent is administered with valproic acid, requiring a lower dosage of lamotrigine... [Pg.258]

MISSELLANEOUS ANTICONVULSANTS. Valproic acid (Depakene) is unrelated chemically to the other anticonvulsants. This drug is absorbed rapidly when taken orally Tablets should not be chewed but swallowed whole to avoid irritation to the mouth and throat. The capsules may be opened and the drug sprinkled on a small amount of food, such as pudding or applesauce This mixture must be swallowed whole immediately and not chewed. Zonisamide is administered orally once a day or in divided doses. The dose may be increased by 100 mg day every 1 to 2 weeks until control of the seizures is obtained or the patient reaches the maximum dosage of 600 mg/d. [Pg.260]

Valproic acid, like short chain fatty acids is volatile and therefore enormous methods have been recommended for its determination in dosage forms and biological fluids. These methods are shown in Table 7. [Pg.231]

The most frequent side effects are diplopia, drowsiness, ataxia, and headache. Rashes are usually mild to moderate, but Stevens-Johnson reaction has also occurred. The incidence of the more serious rashes appears to be increased in patients who are also receiving valproic acid and who have rapid dosage titration. Valproic acid substantially inhibits the metabolism of lamotrigine. [Pg.607]

Adjunctive therapy - Divalproex sodium or valproic acid may be added to the patient s regimen at a dosage of 10 to 15 mg/kg/day. The dosage may be increased by 5 to 10 mg/kg/wk to achieve optimal clinical response. Ordinarily, optimal clinical response is achieved at daily doses less than 60 mg/kg/day. If satisfactory clinical response has not been achieved, measure plasma levels to determine whether they are in the usually accepted therapeutic range (50 to 100 mcg/mL). If the total daily dose exceeds 250 mg, administer in divided doses. [Pg.1240]

Pharmacology This group includes valproic acid, sodium valproate (the sodium salt), and divalproex sodium (a compound containing equal proportions of valproic acid and sodium valproate). Regardless of form, dosage is expressed as valproic acid equivalents. [Pg.1242]

Seizure control in patients receiving enzyme-inducing antiepileptic drug (ElAEDs), hut not valproic acid PO Recommended as add-on therapy 50 mg once a day for 2 wk, followed by 100 mg/day in 2 divided doses for 2 wk. Maintenance Dosage may be increased by 100 mg/day every week, up to 300-500 mg/day in 2 divided doses. [Pg.672]

The sodium salt of valproate is marketed in Europe as a tablet and is quite hygroscopic. In Central and South America, the magnesium salt is available, which is considerably less hygroscopic. The free acid of valproate was first marketed in the USA in a capsule containing corn oil the sodium salt is also available in syrup, primarily for pediatric use. An enteric-coated tablet of divalproex sodium is also marketed in the USA. This improved product, a 1 1 coordination compound of valproic acid and sodium valproate, is as bioavailable as the capsule but is absorbed much more slowly and is preferred by many patients. Peak concentrations following administration of the enteric-coated tablets are seen in 3-4 hours. Various extended-release preparations are available not all are bioequivalent and may require dosage adjustment. [Pg.524]

Q5 Carbamazepine or valproic acid can be used in treating bipolar disorder and are useful for patients who are unresponsive to lithium. Initially, carbamazepine may be given in a divided dose of 400 mg daily. The normal dosage range can increase to 600 mg daily in divided doses, although a maximum dose of 1600 mg daily may be needed in some patients. The initial dosage for valproic acid is 750 mg daily in two or three divided doses, increasing to 1 -2 g daily if necessary. [Pg.114]

PLATINUM COMPOUNDS ANTIEPILEPTICS -CARBAMAZEPINE, PHENYTOIN, VALPROIC ACID l plasma concentrations of antiepileptic, which t risk of seizures Due to impaired absorption of antiepileptic Monitor closely for seizure activity and warn patients and carers. Need to adjust dosage using parameters such as blood levels to ensure therapeutic levels... [Pg.332]

The most important interactions of tiagabine involve induction of its metabolism by enzyme-inducing anticonvulsants (30). This results in larger tiagabine dosage requirements compared with patients taking monotherapy or valproic acid co-medication. [Pg.3421]

Thrombocytopenia can be caused by autoimmune mechanisms (SED-13, 150) (54), tends to be related to high serum drug concentrations, and often responds to dosage reduction (SEDA-19, 74). Of 131 patients randomized to high plasma concentrations of valproic acid (80-150 gg/ml), 36 (27%) had at least one platelet count below 75 X 10 /1, compared with only one patient in a group randomized to drug concentrations of 25-50 gg/ml (55). [Pg.3583]

For drugs with short half-lives (30 min to 3 h) and a relatively narrow margin of safety, the use of an inconveniently short dosage interval (< 6 h) would be required to maintain plasma concentrations within the therapeutic range. This situation applies to carbamazepine and valproic acid (anticonvulsants), which are commercially available as conventional oral dosage forms. For drugs with a... [Pg.147]

Valproic Acid. Valproic acid (VPA), is available in several chemical forms, including valproic acid, sodium valproate, and divalproex sodium, a stable coordination compound containing equal proportions of valproic acid and sodium valproate. In either of these forms, the dosage is expressed as valproic acid equivalents (Table 6.1) (18).Oral valproic acid derivatives are rapidly absorbed the absolute bioavailability of divalproex extended-release (ER) tablets was about 90% relative to that of the intravenous infusion. The ER form had an average bioavailability of 81 -89%compared to that of divalproex delayed-release tablets given twice daily. The relationship between plasma concentration and clinical response is not clear. This may be attributed to the nonlinear concentration-dependent protein binding of valproic acid, which in turn affects the clearance of the agent (18). [Pg.275]

KENT Does the patient have gingival hyperplasia caused by phenytoin Does the patient have thrush or stomatitis that could be caused by a medication Does the patient have dry eyes caused by an anticholinergic medication effect Has the patient noted hair loss that could be due to valproic acid Is the patient able to swallow solid dosage forms. Does the patient complain of vertigo that could be medication induced ... [Pg.586]


See other pages where Valproic acid dosage is mentioned: [Pg.1044]    [Pg.458]    [Pg.1044]    [Pg.458]    [Pg.257]    [Pg.578]    [Pg.597]    [Pg.599]    [Pg.599]    [Pg.602]    [Pg.244]    [Pg.1229]    [Pg.320]    [Pg.380]    [Pg.673]    [Pg.319]    [Pg.641]    [Pg.320]    [Pg.16]    [Pg.312]    [Pg.150]    [Pg.662]    [Pg.111]    [Pg.286]    [Pg.915]    [Pg.1995]    [Pg.2092]    [Pg.165]    [Pg.72]    [Pg.73]    [Pg.119]    [Pg.164]   
See also in sourсe #XX -- [ Pg.165 , Pg.166 ]




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Valproic acid

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