Validation of Differentially Expressed Proteins

Alterations in the protein pattern are immanent for mammalian body fluids or tissues. Differential expression profiles for the comparison of distinct samples are to be expected due to the biological variability related to patient age, gender or lifestyle. In order to distinguish disease-related features from false-positive differences the critical validation and assessment of putative markers is of fundamental importance (Zolg and Langen, 2004). 

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Adkins, J. N., Pounds, ). G., Fagan, R., etal. (2004). The human plasma proteome a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3, 311-326. 

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