Vaginal rings Danazol

Igarashi, M., et al. 1998. Novel vaginal danazol ring therapy for pelvic endometriosis, in particular deeply infiltrating endometriosis. Hum Reprod 13 1952. 

Rings containing danazol were designed to control and treat pelvic endometriosis. Danazol acts directly on endometriotic tissue, inhibits DNA synthesis, and induces cell apoptosis. Danazol locally administered did not show inhibition of ovulation on the contrary, oral administration produced a lack of menstrual cycle. Consequently, the main mechanism of action after local administration was reported to be the direct action on endometriotic cells. Danazol probably diffuses through vaginal mucosa and reaches the deep layers, where infiltrating endometriosis takes place. This behavior allows for the avoidance of the side effects, which characterize oral therapy [41]. 

Danazol Treatment of pelvic endometriosis Ring and vaginal suppository Effective without increased serum concentrations observed during oral therapy 114... 

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