Vaginal adenocarcinoma

Diethylstilbestrol All Vaginal adenosis, clear cell vaginal adenocarcinoma... 

Estrogens are contraindicated in patients with estrogen-dependent neoplasms such as carcinoma of the breast or endometrium. Vaginal adenocarcinoma has been reported in young women whose mothers were treated when pregnant with them with diethylstilbestrol in an effort to prevent miscarriage. 

DES given during breast feeding —>T vaginal adenocarcinoma CA in offspring... 

T breast cancer—questionable, but caution if other risk factors are present 0 DES given during breast feeding —vaginal adenocarcinoma cancer in offspring... 

Diethylstilboestrol (DES) is a synthetic oestrogen that used to be prescribed to prevent miscarriages until 1977. Its role in the development of vaginal adenocarcinoma and cervical dysplasia is known and screening is codified. Recent cohort studies have shown that exposure to DES in utero increases the risk of a broad spectrum of gynaecological and non-gynaecological adverse conditions in adult women who were prenatally exposed to DES >40 years ago. 

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