V-nitrosopyrrolidines

V-Nitrosopyrrolidine. Pyrrolidine, 1-nitroso- (8,9) (930-55-2) Ethyl nitrite Nitrous acid, ethyl ester (8,9) (109-95-5)... 

In fact, several of the cigarettes which were machine smoked earlier and analyzed without precautions, when smoked by us under the same conditions but with precautions, yielded 25 to 100% lower values for DMN [A-nitrosodimethylamine] and NPY [V-nitrosopyrrolidine] for the mainstream smoke... The nitrate content of the tobacco appears to be a determining factor for the concentration of volatile nitrosamines in the smoke. Selective removal of these nitrosamines does occur with cellulose acetate filter tips but not with charcoal filter tips. 

Broadly, NOC are divided into two groups (a) /V-nitrosamines and (b) N-nitrosamides. In jV-nitrosamines, the two remaining substituent groups on the >N—N=0 atom can be either alkyl or aryl, or they can form the part of a heterocyclic ring (as in N-nitrosopyrrolidine). On the other hand, in N-nitrosamides, more correctly called N-acyl-N-nitroso compounds, one of these... 

A/-nitrosopyrrolidine (NPYR) A/-nitrosopiperidine (NPIP) /V-nitrosothiazolidine A/-nitrosomorpholine (NThZ) (NMOR) ... 

The potent carcinogen A -nitrosopyrrolidine has been linked to deoxynucleotides as in structure 133 u.v. irradiation in the presence of DNA caused chain-scission to occur. 

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