UV-induced apoptosis

Wang Y, Li G (2006) 1NG3 Promotes UV-induced Apoptosis via Fas/Caspase-8 Pathway in Melanoma Cells. J Biol Chem 281 11887-11893... 

Luo, K.Q., Yu, V.C., Pu, Y., and Chang, D.C., Application of the fluorescence resonance energy transfer method for studying the dynamics of caspase-3 activation during UV-induced apoptosis in hving HeLa cells, Biochem. Biophys. Res. Commun., 283, 5, 1054, 2001. 

In addition to receptor-mediated apoptosis (see 15.5), there is another main pathway activated by various forms of cellular stress. Examples of stress effects that can induce apoptosis are y- and UV-radiation, treatment with cytotoxic drugs such as actinomycin D and removal of cytokines. As a consequence of stress, procaspase 8 is activated by a... 

Inhibition of Icmt by adenosine and homocysteine or AGGC has also been proposed to induce apoptosis in pulmonary artery ECs by two distinct mechanisms involving Ras and RhoA [75,76]. The first proposed mechanism was the attenuation of Ras-stimulated Erk and Akt signaling. Evidence for this consisted of the ability of active H-Ras to overcome the effects of adenosine and homocysteine, as well as the ability of dominantnegative H-Ras to induce apoptosis in the absence of adenosine and homocysteine [75]. The second mechanism proposed was that inhibition of Icmt induces apoptosis by causing dysfunction of the ER unfolded protein response (UPR), potentially due to a subcellular relocalization, aggregation, and decrease in protein level of the ER molecular chaperone GRP94. This apoptotic phenotype could be rescued upon expression of active RhoA [76]. Overexpression of Icmt-GFP was also found to protect ECs from apoptosis induced by UV, TNFot, and adenosine and homocysteine [75]. 

Yabu, T., S. Todoriki and M. Yamashita. Stress-induced apoptosis by heat shock, UV and y-ray irradiation in zebrafish embryos detected by increased caspase activity and whole-mount TUNEL staining. Fish. Sci. 

Radical prodnction is the essence of the action of certain drugs, some antibiotics, and psoralens they may be activated by UV light, while the male contraceptive gossipol acts via ROS formation, the ROS damaging the spermatozoa motility (Bartosz, 1995). Becanse ROS induce apoptosis, they are experimented with in selective killing of cancer cells (Sen et al., 1998 Heimli et al., 2001)... 

Scott M, Bonnefin P, Vteyra D et al. UV-induced binding of INGl to PCNA rrgulates the induction of apoptosis. J Cell Sci 2001 114 3455-3462. 

RundelPW (1978) The ecological role of secondary lichen substances. BiochemSystEcol 6 157-170 Russo A, Piovano M, Lombardo L et al (2008) Lichen metabolites prevent UV light and nitric oxide-mediated plasmid DNA damage and induce apoptosis in human melanoma cells. Life Sci 83 468-474... 

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