Use of Supramolecular Inclusion Complex

There are few examples using a supramolecular inclusion complex as intermediate for the monofunctionalization of cyclodextrins, when this approach should give good results. 

Mono-2-tosyl-P-cyclodextrin 17 was prepared using a group transfer strategy [27]. meto-Nitrophenyl tosylate reacts with p-cyclodextrin 2 in a DMF/water buffer 

However, a defined structure is not always needed. For example, random methy-lation can produce a 3-cyclodextrin derivative in which an average of 1.5 hydroxyl functions per glucose unit is methylated. This pattern enhances the solubility of the cyclodextrin in water, without affecting its ability to form supramolecular inclusion complexes. This has been proven useful in applications such as the extraction of cholesterol or the detoxification of polluted waters [3]. 

Clearly, a better strategy is needed in order to access multidifferentiated cyclodextrins in an efficient way. 

---

In this chapter, we present methodologies that have proven successful to access different patterns of functionalization and differentiation based on the approach developed toward selectivity difference of reactivity between the diSerent positions, control of the number of equivalents of reagents, use of supramolecular inclusion complexes, capping reagents, bulky protecting groups, and steric hindrance during deprotection. 

---