Use of Stochastic Modeling Results

The linearized multi-stage procedure leads to a plausible upper limit to the dose-response relationship at doses below the range of observation that is consistent with some proposed mechanisms 

Estimates of responses at low doses derived from data on laboratory animals and extrapolated to humans are complicated by a variety of factors that differ among species and potentially affect the response to hazardous chemicals. These factors include differences between humans and experimental test animals with respect to life span, body size, genetic variability, population homogeneity, existence of concurrent disease, such pharmacokinetic effects as metabolism and excretion patterns, and the dosing regimen. These factors are discussed further in Section 3.2.1.5. 

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