Use of KL-3 in Experimental and Clinical Surgery

The antibody composition of skeletal muscles joined with ICL-3 does not differ from that of conventionally sutured muscles [438], which indicates that the preparation has no allergenic effects. 

The KL-3 adhesive allows reliable gluing together of the musculo-aponeurotic leaves of anterior abdominal wall in rabbits luider conditions of high mechanical loading [438], which allows use of this preparation in the clinical plasty of massive hernias. 

In experiments on rabbits and dogs, a method was worked out for closing colonic fistulas with the KL-3 adhesive [439] as follows. A pol5winyl chloride probe with 1—1.5 ml of the adhesive at its end is drawn into the fistula canal. Then the probe is gradually drawn out and simultaneously the adhesive fills the fistula canal, being pressurized by means of a syringe. Adhesive polymerization occurs immediately in the fistula canal. 

Pneumopression tests showed that there is no loss of integrity of the intestine in the region of a colonic fistula closed with the adhesive [441]. Tests using the adhesive labeled with showed that the biodegradation products do not cumulate in organs and tissues [442]. 

Fragmentation of the adhesive mass and the through-growth of connective tissue occurred in 14 days [443] 2-3 months later, connective tissue scarring was formed at the site of inflammatoiy infiltrate in the gut wall. Replacement of the adhesive filling for the coimective tissue was necessary only after one year. This method of closing intestinal fistulas has been successfully used in clinical practice [444, 445]. 

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