Use of Cultured Mammalian Cells to Screen for Genetic Toxicity

3 Use of Cultured Mammalian Cells to Screen for Genetic Toxicity 

Describe the design of an acute-toxicity test. Define the LDjq derived from 

Which tends to be more conserved through evolution (a) the doses of chemicals that cause toxic effects, or (b) the relative potencies of toxic chemicals Explain how these two types of information might be combined to estimate the TD50 of a chemical, X, in humans from its TD50 in rats. 

Describe three exposure scenarios in single-generation tests for reproductive toxicity. Name one toxic endpoint for each of the three exposure scenarios. 

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