Urinary NOx

We selected one renal hypouricemia patient with a history of ALPE and one healthy adult (control) without a history of ALPE, and measured creatinine clearance, FEUA, and oxidative stress markers (urinary 8-isoprostane and NOx) after anaerobic and aerobic exercise load tests (a 400-m race, 16 min on a treadmill, Bruce method, 13.5metabolic equivalents (METs)) (Fig. 67). In the hypouricemia patient, (a) exercise reduced creatinine clearance (Fig. 68), (b) FEUA increased 5h after the exercise load test (Fig. 69), (c) the urinary 8-isoprostane level increased slightly 6-25h after the exercise load test, although there were no marked differences compared with the control values (Fig. 70), and (d) the urinary NOx level increased 2 and 5h after the exercise load test (Fig. 71). Thus, we found that exercise reduced creatinine clearance in the renal hypouricemia patient with a history of ALPE, but there was no marked influence of oxidative stress. 

Fig. 71. Exercise loading and levels of urinary stable metabolites of NO (NOx). The changes in urinary NOx after exercise differed between a patient with a history of ALPE and the control...

In Fe-loaded rats both plasma and renal tissue malondialdehyde and renal tissue nitrotyrosine were increased significantly compared with control rats (Zhou et al. 2000). Fe-depleted animals showed a marked reduction in plasma and renal tissue malondialdehyde and nitrotyrosine together with significant elevation of urinary NOx excretion. In addi-... 

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