Uridine diphosphate glucose UDPG

Leloir determined the pathway to uridine diphosphate glucose (UDPG). 

Uridine-diphosphate-glucose (UDPG) Guanosine 5 -diphosphate-3 -diphosphate C15H24N2O17P2 (566.3) 10.9 7.5 1 1 ... 

In a synthesis of coenzyme uridine-diphosphate-glucose (UDPG), Todd and coworkers protected the primary 5-hydroxyl group of uridine (5) by tritylation, benzylated the 2- and 3-hydroxyl groups (6), and removed the trityl group with 80% acetic acid. 

Glucose-l-phosphate and luidine triphosphate in the presence of UDPG pyrophosphorylase form uridine diphosphate glucose (UDPG) and pyrophosphate (see Fig. 2). Glucuronic acid is derived from UDPG... 

The search for the corresponding enzyme vomilenine 21-O-p-D-glucosyltransferase was successful only when microsomal proteins were analyzed for the enzyme activity. The transferase reaction was dependent on active protein in the presence of substrate vomilenine and cosubstrate uridine diphosphate glucose (UDPG) (the orJy one accepted from several tested UDP monosaccharides). However, the transferase was far less specific for the nucleotide part of the cosubstrate. Enzyme activity was only detected in a Rauuolfia cell suspension which produces the glucoalkaloid rau-caffricine (30). Inhibition of this membrane-bound transferase might probably enhance ajmaline production in Rauuolfia which has, however, not yet been proven so far. 

Yeast cells produce two storage polymers, trehalose (a disaccharide) and glycogen. In addition they synthesize the mannan and glucan components of the cell wall (see Chapter 16). The synthesis of both storage polymers commences with the formation of uridine diphosphate glucose (UDPG) catalysed by UDPG-pyrophosphorylase ... 

Glycogen is a complex polysaccharide made up of condensed glucose residues (see Chapter 2) and has the ability to add on further glucose units when they become available within the body. The actual source material for glycogen synthesis is uridine diphosphate glucose (UDPG), which is produced from a variety of sources as shown in Fig. 9.22. 

Uridine triphosphate (UTP) + Glucose-1-phosphate pytophl phorylas Uridine diphosphate glucose (UDPG) + Pyrophosphate... 

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