Uric acid recognition

The file Is used routinely In the laboratory at the National Institutes of Health In an attempt to explain abnormal test results The resident physicians affiliated with the Clinical Chemistry Service discuss the results with the patient-care physicians and determine If the results were due to the patient s clinical state or to a drug effect This close monitoring of test results has led to recognition of deficiencies In what Is believed are specific enzymatic procedures for the measurement of glucose and uric acid Likewise, the gualac procedure for occult blood In feces was found to yield false negative results under certain circumstances This has prompted the development of a more specific procedure (Jaffe et al unpublished) ... 

MIP membranes were prepared for the recognition of water soluble L-glutamine [218], tetracycline [221], uric acid [223], theophylline [216, 222] and naringin... 

The isolation of allantoin (7), after lead peroxide oxidation of uric acid was followed by the recognition of other oxidation products, the main product of which are oxonic acid (8), allantoxaidine (9) and oxaluric acid (HjNOCHNCOCOjH). Their structures have been clarified by comprehensive studies using isotopically labeled compounds. ... 

Two different systems for the detection of dopamine and uric acid, respectively, have recently been reported in the literature. Both are based on the same detection technique, that of chemiluminescence (CL). In the first one, a chemiluminescence biosensor has been assembled using whole vegetable tissue (fresh mature potato root) as molecular recognition element [155]. 

The prognosis in APRT deficiency clearly depends on the renal function at the time of diagnosis. This underlines the importance of early recognition and appropriate treatment. Allopurinol, — without alkali— will inhibit the formation of the nephrotoxic 2,8-DHA, and thus effectively prevent what should be an essentially benign disorder becoming a potentially lethal one. The long-term effect of allopurinol therapy with its potential for adenine accumulation, particularly in those cases with severe renal damage, remains to be established. All supposed uric acid stones should be submitted for analysis by special techniques to avoid any further confusion in the future. 

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