UPDRS Rating Scale

The most useful diagnostic tool is the clinical history, including both presenting symptoms and associated risk factors. The Unified Parkinson s Disease Rating Scale (UPDRS) is used to define the degree of disability. 

UPDRS Unified Parkinson s Disease Rating Scale... 

All of the more recent compounds have been tested in randomized double-blind clinical trials using the Unified Parkinson s Disease Rating Scale (UPDRS). We do not however have studies comparing the different drugs nor different treatment durations. In addition, the length of these trials is totally different from that of the natural disease course (20 years). It is paradoxical that levodopa, developed in the sixties, remains today the mainstay treatment for Parkinson s disease (levodopa is always associated with a peripheral decarboxylase inhibitor, either car-bidopa or benzerazide). 

United Parkinson Disease Rating Scale (UPDRS) useful for monitoring efficacy endpoints... 

Fahn S, Elton RL, UPDRS Development Committee (1987) Unified Parkinson s Disease Rating Scale. In Fahn S, Marsden CD, Goldstein M, Caine DB (Eds), Recent Developments in Parkinson s Disease, pp. 153-163. MacMillan Health Care Information, New York. 

In the MPTP monkey model, like in humans, MPTP produces Parkinson-like symptoms that can be assessed by a modified Unified PD Rating Scale (UPDRS), the most commonly used tool for the evaluation of PD symptoms in humans. 

Table 14.1 Dyskinesias as rated in the UPDRS and Rush Dyskinesia Scale.

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