Universal bioanalytical method

The possibility of replacing the plasma matrix diluent with water is particularly useful in preclinical studies where a very wide quantifying range is requested to accommodate the variable concentration of analyte in the study samples. The universal bioanalytical method employs ... 

F. Garofolo, H. Pang, M. McIntosh, E. Wong, M. Kennedy, and A. Marland, Universal bioanalytical method theory UBM, Proceedings of the 47th ICASS, 2001 (available from http //orchard.uwaterloo.ca/conferences/icass2001/Main.htm). 

Gerhard K.E. Scriba, Friedrich-Schiller-University Jena, School of Pharmacy, Jena, Germany, Bioanalytical Method Validation for Macromolecules... 

In early 1983, Bioanalytical Systems introduced a new class of integrated processor-driven instrumentation based on a concept first developed by Faulkner and his co-workers [1] at the University of Illinois. This unit (Figs. 6.22 and 6.23) has evolved over the years and now includes a repertoire of some 35 electrochemical techniques, including the most popular large-amplitude (Chap. 3) and small-amplitude (Chap. 5) controlled-potential methods. The unit also is capable of determining electrocapillary curves and can automatically measure and compensate for solution resistance (R in Fig. 6.5). Thus in a single instrument it is possible to utilize virtually all of the diagnostic criteria introduced in Chapters 3 and 5 and also to explore quickly which technique is optimum for... 

Martin, L.E. Reid, E. In "Progress in Lrug Metabolism" Bridges, J.W. Chasseaud, L.F., Eds. John Wiley Chichester, New York, Brisbane, Toronto, 1981 Vol. 6, pp. 197-248. Lieterle, W. Faigle, J.W. "Preparative Liquid Chromatographic Methods in Lrug Metabolism Studies" presented at the 4th International Bioanalytical Forum, University of Surrey,... 

With the 20 naturally occurring L-amino acids, it is possible to form an immense number of combinations and permutations. For a dipeptide there are already 20 = 400 possible arrangements, for a tripeptide 20 = 8,000. A relatively small protein with 100 amino acid residues can be arranged in 20 ° = 1.27 x 10 different ways, an enormous number, especially when bearing in mind that there are only 10 atoms in the whole universe. The bioanalytical chemist has to face a difficult task, if he wants to determine the exact sequence of amino acids in a protein. Nonetheless, their analysis has become commonplace and the methods involved are discussed in chapter 7. 

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