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United Kingdom Prospective Diabetes Study

The Diabetes Control and Complications Trial (DCCT), the Stockholm Diabetes Intervention Study (DIS), the United Kingdom Prospective Diabetes Study (UKPDS), and the Japanese Kumamoto study show unequivocally that vigorous treatment of diabetes can decrease both the morbidity and mortality of the disease by reducing chronic complications. [Pg.753]

Metformin works best in patients with significant hyperglycemia and is often considered first-line therapy in the treatment of mild to moderate type II overweight diabetics who demonstrate insulin resistance. The United Kingdom Prospective Diabetes Study demonstrated a marked reduction in cardiovascular comorbidities and diabetic complications in metformin-treated individuals. Metformin has also been used to treat hirsutism in individuals with polycystic ovarian syndrome and may enhance fertility in these women, perhaps by decreasing androgen levels and enhancing insulin sensitivity. [Pg.773]

Davis TM et al The continuing legacy of the United Kingdom Prospective Diabetes Study. Med J Austral 2004 180 104. [PMID 14748669]... [Pg.950]

United Kingdom Prospective Diabetes Study (UKPDS) Group Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes UKPDS 34. Lancet 1998 352 854. [Pg.952]

In the United Kingdom Prospective Diabetes Study a subgroup of patients taking sulfonylurea therapy to which metformin was added appeared to have had excess mortality. Data from 263 general practices in the UK were analysed 8488 patients took a sulfonylurea initially, to which metformin was added in 1868 (25). The crude mortality rates per 1000 person years were 59 and 40 respectively. Metformin was used initially in 3099 patients and a sulfonylurea was added in 867. The crude mortality rates per 1000 person years were 25 and 20 respectively. These results suggest there is no increased mortality risk with a combination of a sulfonylurea and metformin. [Pg.369]

Turner, R.C., et al. 1998. Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus United Kingdom Prospective Diabetes Study (UKPDS 23). Br Med J 316 823. [Pg.392]

There is little debate today regarding the benefits of tight glycemic control in type 2 diabetes. Results of the landmark United Kingdom Prospective Diabetes Study demonstrate conclusively that intensive glycemic control significandy influences the development of many of the destructive effects of type 2 diabetes. Over a 10-year period, for example, a reduction of 11 % in the HbAic of patients receiving intensive therapy was associated with a 25% reduction in microvascular complications (114). [Pg.196]

UKPDS (United Kingdom Prospective Diabetes Study) Group. 1998. Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33), Lancet, 352 837-853. [Pg.308]

United Kingdom Prospective Diabetes Study Group, Ann. Intern. Med., 128, 165-175 (1998). [Pg.38]

Metformin should be included in the therapy for all type 2 DM patients, if tolerated and not contraindicated, as it is the only oral antihyperglycemic medication proven to reduce the risk of total mortality and cardiovascular death, according to the United Kingdom Prospective Diabetes Study. [Pg.1333]

Intensive glycemic control is paramount for reduction of microvascular complications (neuropathy, retinopathy, and nephropathy) as evidenced by the Diabetes Control and Complications Trial in type 1 DM and the United Kingdom Prospective Diabetes Study (UKPDS) in type 2 DM. The UKPDS also reported that control of hypertension in patients with diabetes will not only reduce the risk of retinopathy and nephropathy, but also reduce cardiovascular risk. [Pg.1333]

IMPLICATIONS OF THE UNITED KINGDOM PROSPECTIVE DIABETES STUDY... [Pg.1353]

UKPDS United Kingdom Prospective Diabetes Study VAT visceral adipose tissue... [Pg.1364]

United Kingdom prospective diabetes study (UKPDS) 1446... [Pg.1884]

Gray A, Raikou M, McGuire A, et al. Cost effectiveness of an intensive blood glucose control policy in patients with type 2 diabetes economic analysis alongside randomised controlled trial (UKPDS 41). United Kingdom Prospective Diabetes Study Group. BMJ 2000 320(7246) 1373-1378. [Pg.110]

LDL-cholesterol was the best predictor of MI in the United Kingdom Prospective Diabetes Study (UKPDS) [21]. Based on the observational epidemiology, a 1 mmol/L increase in LDL is associated with a 57% increased risk. LDL-cholesterol was also a strong predictor of CVD in diabetic individuals with insulin resistance and relatively low LDL concentrations in the Strong Heart Study [22]. [Pg.175]

See other pages where United Kingdom Prospective Diabetes Study is mentioned: [Pg.649]    [Pg.236]    [Pg.937]    [Pg.997]    [Pg.164]    [Pg.200]    [Pg.223]    [Pg.691]    [Pg.63]    [Pg.254]    [Pg.341]    [Pg.863]    [Pg.1701]    [Pg.5]    [Pg.15]    [Pg.1446]    [Pg.471]    [Pg.471]    [Pg.482]    [Pg.91]    [Pg.199]    [Pg.232]   
See also in sourсe #XX -- [ Pg.1353 , Pg.1363 ]

See also in sourсe #XX -- [ Pg.232 ]



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Kingdom

PROSPECT

Prospecting

Prospective Studies

United Kingdom

United Kingdom Prospective

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