Unilateral lesions

Caballero, A. De Andres, I. (1986). Unilateral lesions in locus coeruleus area enhance paradoxical sleep. Electroencephalogr. Clin. Neurophysiol. 64, 339-46. 

Unilateral lesions can be obtained through different means hemisection, 6-OH-DA and MPTP injections. Supersensitivity is developed at the postsynaptic receptors on the lesioned side, giving rise to an asymmetry in the animals treated. Administration of a DA agonist to a lesioned animal will give rise to a rotating behaviour [51]. 

Casas M, Ferre S, Cobos A, Grau JM, Jane F (1989) Relationship between rotational behaviour induced by apomorphine and caffeine in rats with unilateral lesion of the nigrostriatal pathway. Neuropharmacology 28 407 09... 

Behaviour initiated in animals by dopamine agonists following a unilateral lesion of the nigrostriatal pathway. 

As indicated in Table I, I-III and their R and S optical antipodes were studied for dopaminergic activity in four primary tests (1) stimulation of central DA-sensitive adenylate cyclase (2, 35), (2) displacement of [%]-spiroperidol binding to rat caudate homogenate (35, 40), (3) induction of rotations in rats with unilateral lesions of the left substantia nigra (2, ... 

In addition to ALPE, mild acute renal failure, including dehydration, acute pyelonephritis, and renal pelvic tumors, is visualized as wedge-shaped contrast enhancement [15]. However, acute pyelonephritis and renal pelvic tumors are visualized as unilateral lesions, whereas ALPE is visualized as a bilateral lesion therefore, differentiation is possible. For a definitive diagnosis, the presence of patchy contrast enhancement must be demonstrated when the serum creatinine level is in the range from 1.2 to 3.5 mg/dl. However, as described above, a definitive diagnosis is not always necessary in clinical practice. 

Ingham CA, Hood SH, Taggart P, Arbuthnott GW (1998) Plasticity of synapses in the rat neostriatum after unilateral lesion of the nigrostriatal dopaminergic pathway. J Neurosci 75 4732-4743. 

Ziegler M, Szechtman H (1988) Differences in the behavioral profile of circling under amphetamine and apomorphine in rats with unilateral lesions of the substantia nigra. Behav Neurosci 702 276-88, 327. 

A small percentage of patients with APA or lAH respond to dexamethasone treatment with a normalization of their blood pressure and correction of their biochemical abnormalities. Dexamethasone treatment should be attempted before surgery, particularly in young patients, or when the norma fall in plasma aldosterone concentration after salt depletion and standing does not occur, and no unilateral lesion is seen on radiographs. Also, a trial treatment of spironolactone, an aldosterone antagonist, usually normahzes... 

Anderson LA, Anderson JJ, Chase TN, Walters JR (1995) The cannabinoid agonists WIN55, 212-2 and CP55,940 attenuate rotational behaviour induced by a dopamine Dl but not D2 agonist in rats with unilateral lesions of the nigrostriatal pathway. Brain Res 691 106-114... 

PLA2 is involved in dopaminergic signaling via the D2 receptor. The density of this receptor is increased in basal ganglia circuitry in Parkinsons disease (Cooper et ah, 1996 Guttman, 1992 Schermanet ah. 1989 Graham. 1990 3706). A chronic unilateral lesion... 

Nariai T, DeGeorge JJ, Lamour Y. Rapoport SL In vivo brain incorporation of [1- C]arachidonate in awake rats, with or without cholinergic stimulation, following unilateral lesioning of nucleus basalis magnocellularis. Brain Res 1991 559 1-9. 

Storm-Mathisen We did not observe any obvious effects on behaviour, but we did not make tests and these were unilateral lesions. 

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