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U-pin

U-pin is most comparable to a six-ring hairpin polyamide, likely due to a loss of two hydrogen bond donors upon removal of the y-turn element. Thus, the dimeric Py-lm U-turn element may be thought of as a C,G-specific replacement for the y-tum (Fig. 3.4). In combination with removal of the /9-Ala tail (see below), H-pin and U-pin polyamides could potentially bind purely G,C sites, a sequence type that has been difficult to target with other polyamide motifs. [Pg.127]

Fig. 3.4 Polyamide-DNA binding motifs with equilibrium association constants K,). Hairpin amino-substitution at the a-position of the y-turn residue leads to enhanced binding affinity (10-fold) without loss of specificity, and with higher orientational selectivity and offers potential for further substitution. Cycle Cyclic polyamides show higher affinity than analogous hairpin molecules with the same number of cationic groups and eliminate all possibility of extended 1 1 binding. H-pin and U-pin compared to their non-linked analogs, H-pins and U-pins exhibit higher binding affinity. The black and open circles represent Im and Py rings, respectively diamonds repre-... Fig. 3.4 Polyamide-DNA binding motifs with equilibrium association constants K,). Hairpin amino-substitution at the a-position of the y-turn residue leads to enhanced binding affinity (10-fold) without loss of specificity, and with higher orientational selectivity and offers potential for further substitution. Cycle Cyclic polyamides show higher affinity than analogous hairpin molecules with the same number of cationic groups and eliminate all possibility of extended 1 1 binding. H-pin and U-pin compared to their non-linked analogs, H-pins and U-pins exhibit higher binding affinity. The black and open circles represent Im and Py rings, respectively diamonds repre-...
The power distribution in the Phoenix Core was determined from fission product activity traverses of " U pins, Pu wands, and removable fuel plates. The peak power, used to determine maximum operating power, was found to occur in the fuel-follower section of an interior shini element, about an inch below the bottom of the fixed fuel core. The ratio of this peak to the core average was 4.3 0.5. [Pg.269]

T ndle Yi ld Siren th of the Tool lotnt Pin U based on 130 d00 pof Yield and the Oro Sectional Area at the Root of the Thread S/8 inch from the Shouldec. 4 Torsional Yield Slrtn lh of the Drill Pipe li Baaed on i Shear Sti n th of S7.7%of the Minimum Yield Stienflh. [Pg.752]

About 5 ml of sample is withdrawn for every 4-6 hours. The absorbance reading of the sample at 580 nm was measured using a Hitachi U-2000 spectrophotometer. The sample is filtered in a vacuum through Whatman filter paper with a pore size of 2.5 pin and diameter of 47 mm. The dry weight of cells is measured to monitoring microbial cell population and cell density. A plot of optical density reading from the spectrophotometer against cell dry... [Pg.257]

The two asperities in relative sliding are separated from each other at a nominal distance p. One of the asperities is assumed rigid while the other one deforms elastically with a deflection u. The total energy of the pinning center can be written as... [Pg.173]

U.S. Army. 1995. Nuclear and Chemical Weapon and Materiel Chemical Surety. Army Regulation (AR) 50-6, Chapter 3, paragraph 3-15. Unclassified PIN 031680-000. Washington, D.C. [Pg.61]

I0.6.8.I Cladding failure in oxide fuel pins of nuclear reactors. The long-term operational performance of nuclear fuel pins is critically governed by the reactions that occur in the gap between the fuel and its cladding. Ball et al. (1989) examined this for the cases of (1) Zircaloy-clad pellets of U02+, in a pressurised water reactor (PWR) and (2) stainless-steel-clad pellets of (U, P)02+, in a liquid-metal-cooled fast-breeder reactor (LMFBR). In particular they were interested in the influence of O potential on Cs, I, Te and Mo and the effects of irradiation on the gaseous species within the fuel-clad gaps. [Pg.412]


See other pages where U-pin is mentioned: [Pg.1021]    [Pg.69]    [Pg.125]    [Pg.125]    [Pg.127]    [Pg.149]    [Pg.275]    [Pg.945]    [Pg.196]    [Pg.7796]    [Pg.231]    [Pg.251]    [Pg.1021]    [Pg.69]    [Pg.125]    [Pg.125]    [Pg.127]    [Pg.149]    [Pg.275]    [Pg.945]    [Pg.196]    [Pg.7796]    [Pg.231]    [Pg.251]    [Pg.207]    [Pg.620]    [Pg.177]    [Pg.91]    [Pg.131]    [Pg.283]    [Pg.661]    [Pg.223]    [Pg.513]    [Pg.83]    [Pg.383]    [Pg.273]    [Pg.253]    [Pg.69]    [Pg.153]    [Pg.292]    [Pg.554]    [Pg.352]    [Pg.387]    [Pg.387]    [Pg.389]    [Pg.60]    [Pg.140]    [Pg.519]    [Pg.98]    [Pg.98]    [Pg.411]    [Pg.33]   
See also in sourсe #XX -- [ Pg.125 ]




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